克罗米芬与定坤丹对PCOS不孕症临床促排卵和临床妊娠疗效的研究

发布时间：2018-01-25 21:33

本文关键词： 定坤丹多囊卵巢综合征克罗米芬　出处：《中国中药杂志》2017年20期 　论文类型：期刊论文

【摘要】：评价在克罗米芬(CC)+促性腺激素(Gn)基础上,CC与定坤丹对PCOS不孕症患者临床促排卵和临床妊娠疗效的研究,为中药助孕治疗提供思路和方法。选择2015年10月1日—2017年4月23日在江苏省中医院生殖医学科门诊行促排卵治疗的PCOS不孕症患者60例。按随机数字表法分为A组[CC+Gn+人绒毛膜促性腺激素(HCG)]和B组(CC+Gn+定坤丹)。观察周期排卵率、周期取消率、周期妊娠率、累积妊娠率、排卵日子宫内膜厚度、Gn使用天数和总用量、未破裂卵泡黄素化综合征(LUFS)及卵巢过度刺激综合征(OHSS)发生率。A组的周期排卵率、周期妊娠率、累积妊娠率及排卵日子宫内膜厚度均小于B组,而周期取消率、Gn使用天数及总用量均大于B组,且差异均具有统计学意义(P0.05)。该研究未出现1例LUFS或OHSS。CC与定坤丹对PCOS不孕症患者具有促排效应,且CC+Gn+定坤丹联合促排方案能显著提高临床妊娠率。
[Abstract]:In the evaluation of clomiphene (CC) + gonadotropin (Gn) on the basis of CC and Ding Kundan of PCOS patients with infertility clinical ovulation and clinical pregnancy outcomes, to provide ideas and methods for traditional Chinese medicine to help pregnant treatment. 60 PCOS patients with infertility from October 1, 2015 April 23, 2017 ovulation treatment in Jiangsu Province Traditional Chinese Medicine Hospital outpatient department of reproductive medicine for the patients. Were randomly divided into A group [CC+Gn+ human chorionic gonadotropin (HCG) and B group (CC+Gn+ Ding Kundan). To observe the cycle ovulation rate, cycle cancellation rate, pregnancy rate and cumulative pregnancy rate of ovulation, endometrial thickness, Gn days and total amount of luteinized unruptured follicle comprehensive syndrome (LUFS) and ovarian hyperstimulation syndrome (OHSS) incidence rate of group.A cycle ovulation rate, pregnancy rate and cumulative pregnancy rate of ovulation and endometrial thickness were less than B group, and the cycle cancellation rate, Gn duration and The total dosage was greater than that of the B group, and the difference was statistically significant (P0.05). There were no 1 cases of LUFS or OHSS.CC and Ding Kun Dan had a promoting effect on PCOS infertility patients, and CC+Gn+ Ding Kun Dan joint promotion program can significantly improve the clinical pregnancy rate.

【作者单位】：南京中医药大学;常州市中医医院;
【基金】：南京中医药大学技术开发项目(2017005)
【分类号】：R711.75
【正文快照】： 多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种以慢性无排卵、临床/生化高雄激素血症、多囊卵巢(polycystic ovaries,PCO)和胰岛素抵抗(insulin resistance,IR)为特征的妇科常见病[1]。PCOS与月经失调、不孕及早期妊娠丢失相关,并且成为女性不孕最常见的原因[2-3]。

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