卵巢储备功能下降患者的辅助生殖子代的健康情况研究

发布时间：2018-01-27 08:55

本文关键词： 辅助生殖技术卵巢储备功能下降子代健康　出处：《浙江大学》2015年博士论文　论文类型：学位论文

【摘要】：卵巢储备功能(ovarian reserve)指卵巢产生卵子数量和质量的潜能,其间接反映了卵巢的功能。卵巢储备功能下降(diminished ovarian reserve, DOR)是指有规律月经的育龄女性由于各种已知或不明原因引发的卵巢功能障碍,而导致卵巢对刺激的反应性或生育力较同龄女性下降。卵巢储备功能下降可能涉及了卵子数量、卵子质量和生育潜能三方面的改变。已有研究发现卵巢储备功能下降可能与ART治疗时的卵巢低反应、高移植取消率和妊娠失败相关。目前关于卵巢储备功能下降对卵子质量的影响的研究都是关于卵子的受精能力和受精卵的着床能力改变的研究。迄今尚未有DOR患者的卵子质量是否在影响子代健康的方面有改变的报道。为了弥补这一空白,本研究将符合纳入标准的接受辅助生殖技术治疗并且成功受孕分娩子代的不孕患者按照基础FSH值进行分组,基础FSH值大于10IU/L并小于40IU/L的不孕患者分入DOR组,基础FSH值小于或等于10IU/L的不孕患者分入对照NOR (normal ovarian reserve)组。统计分析显示DOR组患者的获卵数明显少于NOR组。而两组子代的智商和新生儿黄疸、先天畸形、高血压、高血脂、空腹血糖异常、肝功能异常、甲状腺功能异常的发生率,均没有发现明显统计学差异。结论：综上证明DOR不孕患者的卵子质量在影响子代健康方面没有改变。
[Abstract]:The ovarian reserve function (ovarian reserve) refers to the number and quality of eggs to produce ovarian potential, the indirectly reflects the function of ovary. The diminished ovarian reserve (diminished ovarian reserve, DOR) refers to the ovarian dysfunction with regular menstrual women of childbearing age due to a variety of known or unknown causes, which lead to ovarian response to stimuli or female fertility was decreased. The diminished ovarian reserve may involve a number of eggs, egg quality and fertility potential of three aspects of change. It has been found that the diminished ovarian reserve and ovarian response to ART treatment, high graft rate and pregnancy failure. To cancel the current research on the decline of ovarian reserve function influence on egg quality the research is about changing the fertilization ability and the implantation of the fertilized egg ability. So far there is no DOR with egg quality In the health of the offspring are reported. In order to change to fill this gap, this study will meet the inclusion criteria of receiving assisted reproductive technology treatment and pregnancy childbirth offspring of infertile patients with FSH were grouped in accordance with the basic value, the FSH value is greater than 10IU/L and less than 40IU/ L infertility patients were divided into DOR group, foundation the FSH value is less than or equal to 10IU/L infertility were divided into control group NOR (normal ovarian reserve). Statistical analysis showed that the number of oocytes in DOR group were significantly less than NOR group. The IQ and neonatal jaundice, two offspring of congenital malformation, high blood pressure, high blood lipid, fasting blood glucose abnormalities, abnormal liver function. The prevalence of thyroid dysfunction, were found no statistically significant difference. Conclusions: the proof of DOR infertility patients in egg quality effects on offspring health did not change.

【学位授予单位】：浙江大学
【学位级别】：博士
【学位授予年份】：2015
【分类号】：R714.8

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