外阴及直肠阴道隔胃肠道外间质瘤3例临床病理分析

发布时间：2018-01-27 22:38

本文关键词： 外阴肿瘤阴道肿瘤胃肠道外间质瘤直肠阴道隔　出处：《临床与实验病理学杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的探讨外阴及直肠阴道隔胃肠道外间质瘤(extragastrointestinal stromal tumor,EGIST)的临床病理学特征、诊断、鉴别诊断及预后。方法对1例外阴及2例直肠阴道隔EGIST的临床资料、病理学特点、免疫表型、基因突变、治疗及预后进行分析,并复习相关文献。结果例1,59岁,右侧外阴见一肿物,4.4 cm×3 cm×3 cm大小,术后6个月复发。例2,58岁,直肠阴道隔见一7.3 cm×6.1 cm×4.6 cm大小肿物。例3,41岁,直肠阴道隔见一8.6 cm×7.4 cm×6.7 cm大小肿物。镜下见瘤细胞梭形,呈编织状、漩涡状及栅栏状排列,核分裂象均易见。免疫表型:3例CD117、CD34、NES及H-Caldesmon均阳性,SMA、desmin及S-100均阴性;例1和例3 DOG-1呈阳性。3例均存在c-Kit基因11号外显子突变。结论外阴、阴道及直肠阴道隔均可发生EGIST,免疫组化及分子检测有助于诊断和指导治疗。
[Abstract]:Objective to investigate extra-gastrointestinal stromal tumor of vulva and rectovaginal septum gastrointestinal stromal tumors. Methods the clinicopathological features, pathological features, immunophenotype and gene mutation of 1 case of negative and 2 cases of rectovaginal septum EGIST were studied. The treatment and prognosis were analyzed, and the related literatures were reviewed. Results A tumor of 4.4 cm 脳 3 cm 脳 3 cm in the right vulva was seen in the right vulva and recurred 6 months after operation. The rectovaginal septum showed a tumor of 7.3 cm 脳 6.1 cm 脳 4.6 cm in size. A tumor of 8.6 cm 脳 7.4 cm 脳 6.7 cm was seen in the rectovaginal septum. The tumor cells were spindle-shaped, woven, swirling and palisade under microscope. The immunophenotypes of 3 cases of CD117, CD34, NES and H-Caldesmon were negative, both SMAdesmin and S-100 were negative. Exon 11 mutation of c-Kit gene was found in cases 1 and 3 DOG-1. Conclusion EGIST can occur in vulva, vagina and rectovaginal septum. Immunohistochemistry and molecular detection are helpful for diagnosis and treatment.
【作者单位】：河南省人民医院病理科;河南省人民医院放射科;
【分类号】：R737.3
【正文快照】： 消化道以外如网膜、肠系膜、腹膜后等处亦可发生与胃肠道间质瘤(gastrointestinal stromal tumor,GIST)组织形态、免疫表型及分子遗传学类似的肿瘤,称为胃肠道外间质瘤(extragastrointestinal stromaltumor,EGIST)。EGIST临床少见,发生于女性生殖道如外阴、阴道及直肠阴道隔更

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