妊娠前半期甲状腺激素参考值范围的研究

发布时间：2018-01-28 06:40

本文关键词： 妊娠甲状腺激素参考值　出处：《中国现代医学杂志》2015年10期 　论文类型：期刊论文

【摘要】：目的建立妊娠前半期甲状腺激素参考值范围,为诊断、治疗孕妇甲状腺疾病提供参考。方法调查541例产科门诊就诊、进行甲状腺激素检查的健康孕妇,记录其甲状腺激素和甲状腺相关抗体检测结果;收集429例妊娠前半期正常孕妇甲状腺激素、尿碘,建立甲状腺激素参考值范围。参考值范围采用中位数(P50)及双侧限值(P2.5和P97.5)表示。结果妊娠前半期FT3、FT4和TSH中位数分别为4.72 pmol/L、15.61 pmol/L和1.63u IU/ml,参考值范围分别为3.53~6.68 pmol/L、11.15~22.81 pmol/L和0.09~5.06 u IU/ml。13~20周与0~12周比较FT3和FT4差异均有统计学意义(P0.01),TSH和尿碘差异均差异无统计学意义(P0.05)。结论建立妊娠前半期甲状腺激素参考值范围具有重要的临床意义。
[Abstract]:Objective to establish the reference range of thyroid hormone in the first half of pregnancy so as to provide reference for the diagnosis and treatment of thyroid diseases of pregnant women. The results of thyroid hormone and thyroid related antibodies were recorded. Thyroid hormones and urinary iodine were collected from 429 normal pregnant women during the first half of pregnancy. To establish a reference range of thyroid hormone. The reference range was expressed by median P50) and bilateral limits (P2.5 and P97.5). Results FT3 was found in the first half of pregnancy. The median of FT4 and TSH were 4.72 mmol / L 15.61 pmol/L and 1.63 u IU/ml, respectively. The range of reference values was 3.53 ~ 6.68 pmol/L. There were significant differences in FT3 and FT4 between 11.15 ~ 22.81 pmol/L and 0.09 ~ 5.06 u IU/ml.13~20 week and 0 ~ 12 weeks (P < 0.05). P0.01). There was no significant difference between TSH and urinary iodine. Conclusion it is of great clinical significance to establish the reference range of thyroid hormone in the first half of pregnancy.
【作者单位】：南方医科大学第三附属医院内分泌代谢科;南方医科大学第三附属医院检验科;南方医科大学第三附属医院妇产科;Abington
【基金】：院长基金(No:2011005)
【分类号】：R714.1
【正文快照】： School Jenkintown,USA PA 19046)附表妊娠前半期血清FT3、FT4、TSH和尿碘的中位数以及95%参考范围注:壆与前一孕期比较,P0.01孕龄/周例数年龄/岁FT3/(pmol/L)FT4/(pmol/L)TSH/(u IU/ml)尿碘中位数/(μg/L)0~12 125 28.55±3.37 5.02(3.66,7.43)16.71(10.89,26.55)1.61(0.04,

【参考文献】