间皮素对卵巢癌诊断价值的Meta分析

发布时间：2018-01-30 02:04

本文关键词： 间皮素卵巢癌诊断价值 Meta分析　出处：《南京医科大学学报(自然科学版)》2017年04期 　论文类型：期刊论文

【摘要】：目的:通过Meta分析评估血清间皮素对卵巢癌的诊断价值。方法:全面检索Pub Med、Embase、Web of Science、CBMdisc、万方和中国知网等数据库应用间皮素诊断卵巢癌的文献,采用Rev Man 5.3、Stata 12.0和Meta-disc 1.4等统计软件进行分析。结果:有9篇文献共计1 068例患者纳入本次Meta分析,其中卵巢癌患者451例,非卵巢癌患者617例,合并灵敏度为0.80(95%CI:0.76~0.83),合并特异度为0.81(95%CI:0.78~0.84),合并阳性似然比为6.93(95%CI:3.32~14.46),合并阴性似然比为0.24(95%CI:0.16~0.35),合并诊断比值比为45.69(95%CI:17.49~119.35),SROC曲线下面积为0.90,Q=0.83。结论:血清间皮素对于卵巢癌诊断有较高的敏感度及特异度,与其他肿瘤标志物进行联合检测,可作为临床辅助诊断卵巢癌的有效方法。
[Abstract]:Objective: to evaluate the diagnostic value of serum mesothelin in ovarian cancer by Meta analysis. Methods: Pub Medbase Web of Science was searched. Rev Man 5.3 was used for the diagnosis of ovarian cancer using mesothelin in CBMdisc, Wanfang and CCN databases. Stata 12.0 and Meta-disc 1.4 were used to analyze the data. Results: a total of 1 068 patients were included in the Meta analysis. There were 451 cases of ovarian cancer and 617 cases of non-ovarian cancer. The combined sensitivity was 0.8095 CI: 0.760.83). The combined specificity was 0.81 ~ 95CI: 0.780.84 and the positive likelihood ratio was 6.9395 CI: 3.32 / 14.46). The combined negative likelihood ratio was 0.24% 95% CI: 0.16% 0.35%, and the combined diagnostic ratio was 45.69% 95% CI: 17.49% 119.35). The area under the SROC curve was 0.90g / Q 0.83. Conclusion: the serum mesothelin has high sensitivity and specificity in the diagnosis of ovarian cancer and is combined with other tumor markers. It can be used as an effective method for diagnosis of ovarian cancer.
【作者单位】：南京医科大学附属妇产医院妇科;
【基金】：南京医科大学科技发展基金(2005NYDZD23)
【分类号】：R737.31
【正文快照】： 卵巢癌是女性常见的恶性肿瘤之一,由于缺乏特异性的症状和体征,临床上难以及时进行诊断。寻找新的肿瘤标志物,及时、准确的诊断对于卵巢癌的治疗监测、预后评估有着重要意义。间皮素是近年来新发现的一种卵巢肿瘤标志物。研究显示,其在卵巢癌患者肿瘤组织中过表达,预后差,约40

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