三维能量多普勒超声评估宫颈癌新辅助化疗疗效

发布时间：2018-01-31 00:20

本文关键词： 三维能量多普勒超声子宫颈癌新辅助化疗　出处：《中国超声医学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨三维能量多普勒超声在宫颈癌新辅助化疗疗效评估中的应用价值。方法对25例接受新辅助化疗的宫颈癌患者于化疗前及化疗结束后2周行三维能量多普勒超声检查,应用VOCAL功能计算病灶体积,采用血管形成指数(VI)、血流指数(FI)、血管血流指数(VFI)评估病灶在化疗前及化疗后的血流灌注情况,随机收集35例正常人宫颈作为对照组,比较宫颈癌新辅助化疗前后三维能量多普勒超声检查结果的差异。结果 25例宫颈癌患者在新辅助化疗前后和35例正常人宫颈的血流参数比较差异有统计学意义(P0.05)。25例宫颈癌患者中,19例新辅助化疗有效,其中2例病灶消失,17例病灶体积较化疗前变小;6例化疗无效,其中病灶无变化3例,病灶增大3例。化疗有效组的化疗后VI、FI、VFI较化疗前变小(P0.05);化疗无效组的化疗后VI、FI、VFI较化疗前无变化(P0.05)。结论应用三维能量多普勒超声技术检测宫颈癌化疗前后肿瘤血流灌注的变化可反映化疗疗效,为临床优化宫颈癌患者的个体化的治疗方案提供参考意见。
[Abstract]:Objective to evaluate the value of three dimensional power Doppler ultrasound in evaluating the efficacy of neoadjuvant chemotherapy for cervical cancer. Methods 25 patients with cervical cancer receiving neoadjuvant chemotherapy were treated with three dimensional multiple energy before chemotherapy and 2 weeks after chemotherapy. Pleurian ultrasound. VOCAL function was used to calculate the volume of the lesion. The blood flow perfusion was evaluated before and after chemotherapy by using the angiogenesis index (VII), the blood flow index (FII) and the vascular flow index (VFI). 35 cases of normal human cervix were randomly collected as control group. To compare the results of three dimensional power Doppler ultrasonography before and after neoadjuvant chemotherapy for cervical cancer. There were significant differences in blood flow parameters between 25 patients with cervical cancer before and after neoadjuvant chemotherapy and 35 normal controls (. P0.05. 25 cases of cervical cancer. Neoadjuvant chemotherapy was effective in 19 cases, in which 2 lesions disappeared and 17 lesions became smaller than those before chemotherapy. 6 cases had no effect of chemotherapy, 3 cases had no change in focus and 3 cases had enlarged focus. In the effective group, the VFI of VIFI was smaller than that of P0.05 before chemotherapy. VIFI after chemotherapy in the group of ineffective chemotherapy. Conclusion Three-dimensional power Doppler ultrasound can be used to detect the changes of tumor blood perfusion before and after chemotherapy in cervical cancer, which can reflect the effect of chemotherapy. To provide reference for clinical optimization of individualized treatment for cervical cancer patients.
【作者单位】：中山大学附属第三医院超声科;
【基金】：广东省科技计划项目(No.2014A020212486) 广东省医学科学技术研究基金(No.A2015284)
【分类号】：R445.1;R737.33
【正文快照】： 结果25例宫颈癌患者在新辅助化疗前后和35例正常人宫颈的血流参数比较差异有统计学意义(P0.05)。25例宫颈癌患者中,19例新辅助化疗有效,其中2例病灶消失,17例病灶体积较化疗前变小;6例化疗无效,其中病灶无变化3例,病灶增大3例。化疗有效组的化疗后VI、FI、VFI较化疗前变小(P

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