长方案控制性促排卵过程中晚卵泡期孕酮变化趋势对体外受精-胚胎移植结局的影响

发布时间：2018-02-02 21:22

本文关键词： 体外受精-胚胎移植控制性卵巢刺激孕酮人绒毛促性腺激素注射日活产率　出处：《现代妇产科进展》2016年03期 　论文类型：期刊论文

【摘要】：目的:探讨在控制性卵巢刺激(COS)周期中晚卵泡期孕酮(P)水平变化趋势对体外受精-胚胎移植(IVF-ET)结局的影响。方法:回顾分析2013年1月至2014年6月在我中心行IVF-ET长方案助孕治疗的676个周期。按促排卵中晚卵泡期起始日(主导卵泡直径达13mm日)与人绒毛膜促性腺激素(HCG)注射日孕酮水平变化,分为升高趋势组和降低趋势组;按HCG日孕酮水平是否1.0ng/ml将升高趋势组和降低趋势组中新鲜移植周期分别分为A组(P≤1ng/ml)、B组(P1ng/ml)和C组(P≤1ng/ml)、D组(P1ng/ml)。结果:(1)升高趋势组与降低趋势组的卵裂率、优质胚胎率比较,差异有统计学意义(99.65%vs 99.00%,70.57%vs 63.09%;P0.05);(2)A组与B组的临床妊娠率、活产率比较,差异有统计学意义(56%vs 43.00%;50%vs 37.76%,P0.05);C组与D组的临床妊娠率、活产率比较,差异无统计学意义(P0.05)。结论:IVF-ET长方案周期中,COS过程中孕酮变化呈升高趋势的优质胚胎率较降低趋势高;新鲜移植周期,P呈升高趋势时,HCG日P1.0ng/ml,活产率下降;呈降低趋势时,HCG日P水平不影响活产率。
[Abstract]:Objective: To explore the effects of controlled ovarian stimulation (COS) cycle late follicular phase progesterone (P) level change trend of in vitro fertilization and embryo transfer (IVF-ET) outcome. Methods: a retrospective analysis of 676 cycles from January 2013 to June 2014 in our center for IVF-ET protocol assisted reproductive treatment. According to the late follicular ovulation period starting Japan (the dominant follicle diameter up to 13mm days) and human chorionic gonadotropin (HCG) injection on the changes of progesterone level, divided into group increased and decreased HCG level of progesterone group; according to whether 1.0ng/ml will increase the tendency of decreasing group and the group of fresh transfer cycles were divided into A group (P = 1ng/ml), B group (P1ng/ml) and C group (P = 1ng/ml), D group (P1ng/ml). Results: (1) increased with decreasing trend group group cleavage rate, high-quality embryo rate comparison, the difference was statistically significant (99.65%vs 99%, 70.57%vs 63.09%; P0.05); (2) clinical pregnancy group A with the B group Pregnancy rate, live birth rate comparison, the difference was statistically significant (56%vs 43%; 50%vs 37.76%, P0.05); C group and D group, the clinical pregnancy rate, live birth rate comparison, the difference was not statistically significant (P0.05). Conclusion: IVF-ET long project cycle, changes in the process of COS is progesterone trend rate of high quality embryos increased a decreasing trend is high; the fresh transplantation period, P increased, HCG, P1.0ng/ml, the live birth rate decreased; decreased when HCG P level does not affect the live birth rate.

【作者单位】：安徽医科大学附属省立医院;
【基金】：安徽省自然科学基金(No:1308085QH131)
【分类号】：R714.8
【正文快照】： 随着体外受精/卵胞质内单精子注射-胚胎移植(in vitro fertilization/intra-cytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)技术不断发展、日臻成熟,不孕患者治疗成功率得到了极大的提高。其成功关键在于获得高质量的卵子及有良好容受性的子宫内膜。由于在控制性

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