62例输卵管癌临床和病理预后分析

发布时间：2018-02-03 06:58

本文关键词： 输卵管癌临床病理预后　出处：《中国癌症杂志》2017年10期 　论文类型：期刊论文

【摘要】：背景与目的:输卵管癌是妇科罕见的恶性肿瘤,预后较差。该研究通过回顾性分析探讨了输卵管癌的各临床和病理因素对预后的影响,从而为治疗提供依据。方法:回顾性评价62例输卵管癌患者各临床和病理因素对预后的影响。应用Kaplan-Meier方法计算生存期,log-rank检验进行组间比较。通过应用COX比例风险模型对单因素分析有意义的因素进行多因素分析,筛选出有独立显著意义的预后因素。结果:62例输卵管癌患者中位生存期为74个月,3年生存率为78%,5年生存率为63%。国际妇产科联盟(International Federation of Gynaecology and Obstetrics,FIGO)分期、术后残余肿瘤大小、化疗次数是输卵管癌的独立预后因素。P53蛋白阴性者中位生存时间、3和5年生存率均高于P53蛋白阳性者。Ki-67平均比例为58.41%,Ki-67小于等于58%者中位生存时间、3和5年生存率数值上均高于Ki-67大于58%者。结论:输卵管癌的分期、术后残余肿瘤的大小和化疗次数是输卵管癌的独立预后因素。早期诊断,从而早期治疗是改善预后的关键因素。争取肿瘤细胞减灭术最大程度的彻底性,术后予有效、足疗程的化疗才能真正提高输卵管癌患者的生存率。病理检查,尤其是P53蛋白和Ki-67的表达水平,对判断输卵管癌预后有一定的意义。
[Abstract]:Background & objective: fallopian tube carcinoma is a rare malignant tumor in gynecology with poor prognosis. Methods: the influence of clinical and pathological factors on the prognosis of 62 cases of fallopian tube carcinoma was evaluated retrospectively. The survival time was calculated by Kaplan-Meier method. The COX proportional risk model was used to analyze the significant factors in single factor analysis. Results the median survival time of 62 patients with tubal cancer was 74 months and the 3-year survival rate was 78%. The 5-year survival rate is 63. The International Union of Obstetrics and Gynecology (. International Federation of Gynaecology and Obstetrics. Figo stage, postoperative residual tumor size and chemotherapy frequency were the independent prognostic factors. P53 protein negative patients had median survival time. The 3- and 5-year survival rates of patients with positive p53 protein were higher than those with positive p53 protein. The average ratio of Ki-67 was 58.41 and the median survival time of those with Ki-67 less than or equal to 58% was higher than that of those with positive p53 protein. Conclusion: the staging of fallopian tube carcinoma, the size of residual tumor and the number of chemotherapy are independent prognostic factors of tubal carcinoma. So early treatment is the key factor to improve the prognosis. Strive for tumor cell reduction surgery to maximize thoroughness, effective after surgery, the full course of chemotherapy can really improve the survival rate of patients with fallopian tube cancer. Pathological examination. The expression of p53 protein and Ki-67 is of significance in predicting the prognosis of fallopian tube carcinoma.
【作者单位】：复旦大学附属妇产科医院中西医结合科;复旦大学附属妇产科医院病理科;
【分类号】：R737.32
【正文快照】： 原发性输卵管癌是妇科罕见的恶性肿瘤之一,占女性生殖道恶性肿瘤的0.14%~1.80%[1]。自Orthmann在1888年报道了首例原发性输卵管癌后,如何制定更加合理的治疗方案,改善输卵管癌患者的预后,一直是妇科肿瘤医师面临的难题和挑战。本研究回顾性分析了62例输卵管癌患者的临床和病理

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