宫颈高危型人乳头瘤病毒感染与阴道菌群及宫颈局部免疫功能的关系

发布时间：2018-02-05 01:25

本文关键词： 生殖道感染人乳头瘤病毒 T细胞亚群　出处：《中华医院感染学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨宫颈高危型人乳头瘤病毒(HPV)感染与阴道菌群及宫颈局部免疫功能的相关性。方法选取2013年1月-2015年12月医院妇科门诊有生殖道感染症状的患者300名,根据是否有高危型-HPV感染分为高危型-HPV组(高危型-HPV阳性组)123例和对照组(高危型-HPV阴性组)177例,检测所有患者中高危型-HPV感染、阴道菌群和宫颈分泌物CD_4~+ T、CD_8~+ T情况。结果 300例患者中高危型-HPV感染者123例,感染率为41.0%,其中HPV16亚型70例,占56.9%,其次为HPV52亚型,占13.8%。高危型-HPV组乳酸杆菌、衣原体、解脲脲原体、细菌性阴道病的阳性率高于对照组(P0.05),两组人支原体、霉菌和滴虫的阳性率比较差异无统计学意义;高危型-HPV组宫颈分泌物CD_4~+ T和CD_4~+ T/CD_8~+ T均低于对照组(P0.05),两组宫颈分泌物CD_8~+ T比较差异无统计学意义;多因素logistic回归结果显示,衣原体、解脲脲原体是高危型-HPV感染的独立影响因素(P0.05)。结论宫颈高危型人乳头瘤病毒感染与阴道菌群及宫颈局部免疫功能有关,衣原体、解脲脲原体是高危型-HPV感染的独立影响因素。
[Abstract]:Objective to investigate the relationship between high risk HPV infection of cervix and vaginal flora and local immune function of cervix. Methods 300 patients with genital tract infection were selected from January 2013 to December 2015. According to whether there is high risk type of HPV infection, we divided it into high risk type group (high risk type HPV positive group, 123 cases) and control group (high risk type HPV negative group, 177 cases). High risk type of HPV infection was detected in all patients. Results among the 300 patients, 123 cases were infected with high risk type of HPV, and the infection rate was 41. 0%, including 70 cases of HPV16 subtype (56.9%), followed by HPV52 subtype (13. 8%). High risk type HPV group Lactobacillus, chlamydia, chlamydia, chlamydia, chlamydia, chlamydia, chlamydia, chlamydia, chlamydia, lactobacillus and chlamydia. The positive rate of Ureaplasma Urealyticum and bacterial vaginosis was higher than that of control group (P0.05). There was no significant difference between the two groups in the positive rate of mycoplasma, mycoplasma and trichomonas. The levels of CD4T and CD4T / CD8T in high-risk type HPV group were lower than those in control group (P 0.05). There was no significant difference in CD8T between the two groups. Ureaplasma Urealyticum is an independent influencing factor of high risk type of HPV infection. Conclusion High risk HPV infection is related to vaginal flora and local immune function of cervix. Chlamydia Urealyticum and Ureaplasma Urealyticum are independent influencing factors of high risk type of HPV infection.
【作者单位】：杭州市余杭区第二人民医院妇产科;
【基金】：浙江省医药卫生一般研究计划基金资助项目(2014KYB254)
【分类号】：R737.33
【正文快照】： 引起宫颈病变进展的危险性明显高于低危型-HPV感染[1];宫颈HPV感染的传播方式主要为性传播,性活跃的女性HPV的感染率比较高,但HPV感染并不一定都会发展为宫颈癌,多数HPV感染患者都可以通过自身机体免疫力将HPV病毒清除,只有少数HPV感染后机体免疫力不能把病毒清除掉,成为HPV持

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