Ki-67、P16和CK34βE12蛋白对可手术宫颈癌患者的预后价值

发布时间：2018-02-05 18:51

本文关键词： Ki-67 P16 CK34βE12 宫颈癌预后　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨Ki-67、P16、CK34βE12蛋白、患者病理特色及术后辅助诊治方式对可手术的宫颈癌患者的预后价值。办法:运用免疫组化法检测72例宫颈癌术后病理组织中Ki-67、P16、CK34βE12蛋白的表达,联合患者病理特色及诊治方式,以患者疾病进展为研究终点,随访自确诊至疾病进展时间(PFS)。单因素分析运用Kaplan-Meier法,多因素分析运用Cox回归分析。结果:单因素分析显示:ki-67(p=0.006)、CK34βE12(p=0.007)、生产次数(p=0.018)、绝经状况(p=0.008)、民族(p=0.034)、有无疼痛(p=0.008)、肿瘤分期(p=0.000)、肿瘤大小(p=0.015)、淋巴结转移状况(p=0.000)、化疗状况(p=0.016)与患者预后相干。Cox分析结果显示:宫颈癌患者Ki-67表达状况、发病年龄、怀孕次数、生产次数、绝经状况、肿瘤分期、是否深肌层受到侵犯、是否沿子宫侵犯、是否放疗为影响可手术宫颈癌患者PFS的显著性因素(PO.05)。而患者P16和CK34βE12蛋白的表达、肿瘤大小、分化程度、初潮年龄、民族、职业、手术和化疗状况等对PFS无显著影响(PO.05),尚不能作为独立的预后因素。结论:ki-67高表达、低龄、早产、肿瘤分期晚,深肌层及沿子宫受侵犯、放射诊治均为宫颈癌的独立预后因素;P16和CK34βE12蛋白的表达、肿瘤大小、分化程度、初潮年龄、民族、职业、手术和化疗状况仅与预后相干,尚不能作为独立的预后因素。
[Abstract]:Objective: to investigate the prognostic value of Ki-67G P16CK34 尾 E12 protein, the pathological features of patients and the way of postoperative diagnosis and treatment. Methods: the expression of Ki-67P16CK34 尾 E12 protein was detected by immunohistochemical method in 72 cases of cervical carcinoma after operation. Combined with the pathological characteristics and diagnosis and treatment of the patients, the end point of the study was the progression of the disease, and the time from the diagnosis to the progression of the disease was followed up. Kaplan-Meier method was used in univariate analysis. Multivariate analysis using Cox regression analysis. Results: univariate analysis showed that:% ki-67 p0. 006, CK34 尾 E12, p0. 007, p0. 018, menopausal status, P0. 008, P0. 034, pain, stage, p0. 0000, size of tumor p0. 015, lymph node metastasis p0. 0000, chemotherapy status p0. 016) and prognosis of patients. The results of correlation. Cox analysis showed that the expression of Ki-67 in patients with cervical cancer, Age of onset, number of pregnancies, number of births, menopause, stage of tumor, invasion of deep muscle layer, invasion of uterus, The expression of P16 and CK34 尾 E12 protein, tumor size, differentiation degree, menarche age, nationality, occupation, etc. Operation and chemotherapy had no significant effect on PFS, and could not be used as an independent prognostic factor. Conclusion: high expression of Ki-67, low age, premature delivery, late tumor stage, invasion of deep muscular layer and uterus along the uterus. Radiotherapy was an independent prognostic factor for cervical cancer. The expression of P16 and CK34 尾 E12 protein, tumor size, differentiation, menarche age, nationality, occupation, operation and chemotherapy were not independent prognostic factors.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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