DLL4、MVD在上皮性卵巢癌组织中的表达及相关性

发布时间：2018-02-09 06:53

本文关键词： 卵巢癌 Delta样配体微血管密度免疫组织化学　出处：《中国妇产科临床杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的本实验通过检测DLL4、MVD在卵巢正常组织、上皮性良性肿瘤组织、上皮性交界性肿瘤组织、上皮性恶性肿瘤组织中表达情况,探讨二者在卵巢上皮性恶性肿瘤中的相关性,为上皮性卵巢癌的早期诊断提供理论依据。方法利用免疫组化SABC法检测30例卵巢正常组织、30例上皮性良性肿瘤组织、30例上皮性交界性肿瘤组织、30例上皮性恶性肿瘤组织中DLL4、MVD表达情况,进一步分析二者之间的相关性。结果 1 DLL4表达阳性率在恶性肿瘤组织中高于交界性肿瘤组织、良性肿瘤组织、卵巢正常组织,差异有高度统计学意义(P0.01);MVD表达情况:在恶性肿瘤组织中阳性表达率高于其他三组,差异有高度统计学意义(P0.01),在交界性肿瘤组织中阳性表达率高于卵巢正常组织及良性肿瘤组织(P0.01);2在卵巢上皮性恶性肿瘤中,DLL4与MVD呈正相关(rs=0.522,P0.01)。结论推测DLL4通过增加肿瘤血管密度,参与上皮性卵巢癌发展。
[Abstract]:Objective to detect the expression of DLL4MVD in normal ovarian tissues, epithelial benign tumors, epithelial sexual intercourse borderline tumors and epithelial malignant tumors, and to explore the correlation between DLL4 and MVD in epithelial ovarian neoplasms. Methods Immunohistochemical SABC method was used to detect 30 cases of epithelial benign tumor tissue and 30 cases of epithelial sexual intercourse borderline tumor tissue and 30 cases of epithelial malignant tumor. The expression of DLL4MVD in tumor tissue, Results 1 the positive rate of DLL4 expression in malignant tumor tissue was higher than that in borderline tumor tissue, benign tumor tissue and normal ovarian tissue. The positive rate of MVD in malignant tumor tissues was higher than that in the other three groups. The positive expression rate of DLL4 in borderline tumors was higher than that in normal ovarian tissues and benign tumor tissues in epithelial ovarian neoplasms. There was a positive correlation between DLL4 and MVD in epithelial ovarian neoplasms. Conclusion DLL4 may increase the density of tumor blood vessels. Participate in the development of epithelial ovarian cancer.
【作者单位】：成都医学院第一附属医院妇产科;内蒙古包头市中心医院妇产科;
【分类号】：R737.31

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