微波联合干扰素治疗慢性宫颈炎伴高危型人乳头瘤病毒感染的临床观察

发布时间：2018-02-13 15:09

本文关键词： 微波宫颈炎慢性人乳头状瘤病毒重组人干扰素　出处：《医学动物防制》2016年12期 　论文类型：期刊论文

【摘要】：目的观察微波联合重组人干扰素治疗慢性宫颈炎伴高危型人乳头瘤病毒(HPV)感染的临床效果。方法选取2013年12月~2015年6月某院收治的慢性宫颈炎伴高危型HPV感染患者120例,按照随机数字表法分为对照组和观察组,每组60例。对照组患者均在月经干净后3~5 d行微波治疗,观察组在微波治疗2 d后隔天每晚睡前阴道后穹隆纳入重组人干扰素α-2b阴道泡腾胶囊1枚,连用10 d为一个疗程(月经期间停药),连续用药3个疗程。比较两组患者治疗6个月后子宫颈糜烂样改变的有效率及HPV阴转率。结果治疗3个疗程后,观察组总有效率为95.0%,高于对照组的80.0%,差异均有统计学意义(χ2=3.55,P0.05)。观察组高危型HPV感染转阴率为55.0%(33/60),明显高于对照组的35.0%(21/60),差异有统计学意义(χ2=5.67,P20.05)。结论微波联合干扰素治疗慢性宫颈炎伴高危型HPV感染疗效好,且高危型HPV感染的阴转率高,值得临床推广应用。
[Abstract]:Objective to observe the clinical effect of microwave combined with recombinant human interferon in the treatment of chronic cervicitis with high-risk human papillomavirus (HPV) infection. Methods from December 2013 to June 2015, 120 patients with chronic cervicitis associated with high-risk HPV infection were selected. According to the random digital table method, the patients in each group were divided into control group and observation group, 60 cases in each group. The patients in control group were treated with microwave for 5 days after menstruation. In the observation group, 1 recombinant human interferon 伪 -2b vaginal effervescent capsule was added into the vagina fornix before sleep every night after microwave therapy for 2 days. Ten days of continuous treatment were used as a course of treatment. The effective rate of cervical erosion-like change and the rate of HPV negativity were compared between the two groups after 6 months of treatment. Results after 3 courses of treatment, the patients in the two groups were treated for 3 courses. The total effective rate of observation group was 95.0, which was higher than that of control group (80.05%), and the difference was statistically significant (蠂 25.55% P 0.05). The negative rate of high-risk type HPV infection in the observation group was 55.0%, which was significantly higher than that in the control group (35.0% 2160%) (蠂 25.67% P20.050.Conclusion Microwave combined with interferon therapy has statistical significance. Sex cervicitis with high risk HPV infection is effective. And high-risk HPV infection negative conversion rate is worthy of clinical application.
【作者单位】：中国石油天然气集团公司中心医院;
【分类号】：R711.32

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