淋巴细胞免疫治疗复发性流产的效果分析

发布时间：2018-02-13 18:19

本文关键词： 淋巴细胞免疫治疗复发性流产封闭抗体　出处：《现代免疫学》2015年03期 　论文类型：期刊论文

【摘要】：为了探讨淋巴细胞主动免疫治疗不明原因复发性流产患者的疗效,观察封闭抗体对妊娠结局的意义。本研究将门诊筛查确诊为封闭抗体缺乏所致的复发性流产患者120例,随机分为两组。研究组60例,采用淋巴细胞主动免疫治疗,对照组60例,采用传统保胎治疗,比较两组妊娠结局。研究组淋巴细胞主动免疫后复查封闭抗体,比较封闭抗体阳性组及阴性组妊娠结局。结果显示研究组60例中分娩37例,妊娠中期15例,流产8例,妊娠成功率86.7%。对照组60例,已分娩19例,妊娠中期12例,流产29例,妊娠成功率51.6%,两组相比有显著性差异。免疫治疗后,封闭抗体阳性组妊娠成功率88.6%,阴性妊娠成功率56.25%。两组相比差异有统计学意义。研究结果提示淋巴细胞主动免疫能提高封闭抗体缺乏所致复发性流产患者的再次妊娠成功率。
[Abstract]:In order to investigate the efficacy of lymphocyte active immunotherapy in patients with recurrent abortion of unknown cause, and to observe the significance of blocking antibody to pregnancy outcome, 120 patients with recurrent abortion due to lack of blocking antibody were diagnosed by outpatient screening in this study. The study group (n = 60) was treated with active lymphocyte immunotherapy, the control group (n = 60) was treated with traditional fetal preservation therapy, and the pregnancy outcome was compared between the two groups. The results showed that 37 cases were delivered in the study group, 15 cases in the second trimester of pregnancy, 8 cases in abortion, and the success rate of pregnancy was 86.7%. In the control group, there were 19 cases of delivery, 12 cases of second trimester and 29 cases of abortion. The success rate of pregnancy was 51.6. There was a significant difference between the two groups. The success rate of pregnancy was 88.6 in the positive group and 56.25 in the negative group. There was significant difference between the two groups. The results showed that the active lymphocyte immunity could increase the success rate of recurrent abortion caused by blocking antibody deficiency.
【作者单位】：中国医学科学院医学生物学研究所;云南玛莉亚医院;
【分类号】：R714.21

【共引文献】