宫颈鳞癌治疗后HR-HPV转阴规律及其相关因素分析

发布时间：2018-02-14 09:22

本文关键词： 宫颈鳞癌高危型人乳头瘤病毒转阴　出处：《中国妇产科临床杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨宫颈鳞癌患者治疗后高危型人乳头瘤病毒(HR-HPV)感染的转阴规律,并分析影响其转阴的相关因素。方法收集2011年1月至2012年12月在首都医科大学附属北京妇产医院接受治疗的宫颈鳞癌患者148例,其治疗前HR-HPV检测均阳性,观察宫颈鳞癌治疗后HR-HPV感染的转阴情况。结果 (1)148例宫颈鳞癌患者接受治疗后,至随访期结束HR-HPV转阴的患者共134例(90.5%);(2)其中随访0.5、1、1.5、2、2.5及3年后HR-HPV转阴率分别为68.9%、73.0%、77.7%、83.1%、86.5%及87.8%;(3)不同时间HR-HPV转阴的速率不同,以2年内转阴的速率最快,之后减慢;(4)单因素及多因素分析均显示临床分期、治疗方案及HPV分型是影响HR-HPV转阴的因素(P0.05),而年龄、组织学分级、吸烟及是否使用安全套不是影响HR-HPV转阴的因素(P0.05)。结论 (1)宫颈鳞癌治疗后HR-HPV转阴率逐年升高,半年内转阴率达68.9%,以2年内转阴速率最快;(2)临床分期、治疗方案及HPV分型是影响HR-HPV转阴的主要因素。
[Abstract]:Objective to investigate the negative transformation of high-risk human papillomavirus (HR-HPVV) infection in patients with cervical squamous cell carcinoma (SCC) after treatment. Methods from January 2011 to December 2012, 148 patients with cervical squamous cell carcinoma who received treatment in Beijing Obstetral Hospital affiliated to Capital Medical University were analyzed. The results showed that HR-HPV was positive before treatment. To observe the turning negative of HR-HPV infection after treatment of cervical squamous cell carcinoma results 148 cases of cervical squamous cell carcinoma were treated. There were 134 patients with HR-HPV turning to negative at the end of follow-up period. Among them, the rate of negative conversion of HR-HPV was 68.9% and 73.7%, respectively, and the rate of negative conversion of HR-HPV was 86.5% and 87.8%, respectively. The rate of negative conversion of HR-HPV was the fastest in 2 years, and the rate of negative conversion was the fastest in 2 years. The univariate and multivariate analysis showed that the clinical stage, treatment regimen and HPV classification were the factors influencing the negative conversion of HR-HPV (P 0.05), while age, histological grade, and age. Smoking and condom use are not the factors influencing HR-HPV negative conversion. Conclusion: after treatment, the rate of HR-HPV turning negative is increasing year by year, and the rate of turning negative within half a year reaches 68.9%, and the fastest rate of negative conversion in 2 years is the clinical stage, conclusion: 1) after treatment, the rate of HR-HPV turning negative is increasing year by year, and the rate of turning negative within half a year is 68.9%. The treatment scheme and HPV classification were the main factors affecting the negative conversion of HR-HPV.
【作者单位】：首都医科大学附属北京妇产医院妇瘤科;

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