子痫前期孕妇动态血压与随机尿蛋白肌酐比、肾功能的关系

发布时间：2018-02-16 02:09

本文关键词： 子痫前期动态血压随机尿蛋白肌酐比肾功能　出处：《实用医学杂志》2016年21期 　论文类型：期刊论文

【摘要】：目的:探讨子痫前期孕妇24 h动态血压的特点,昼夜血压节律的变化与尿蛋白肌酐比(ACR)、肾功能损害的关系。方法:收集子痫前期孕妇80例进行分析,根据病情分重度组(A组)35例,轻度组(B组)45例,并选取同期年龄、孕次、体重类似的正常孕妇40例为对照组(C组)。所有研究对象均行24 h动态血压监测(ABPM),分析24 h血压的特点及昼夜节律性。随机留取中段尿行ACR检测,比较3组ACR及肾功能指标水平。对子痫前期孕妇ABPM指标与随机ACR、肾功能指标行相关性分析。结果:(1)A组24 h SBP、24 h DBP、d SBP、n SBP、n DBP、d MAP、n MAP、SL、d HR、n HR、24 h HR明显高于B组(P0.05)。A及B组MBP10%,昼夜血压呈"非杓型"改变A组占88%,B组占67%。(2)A组血BNU、SCR、SUA及ACR均明显高于B、C组,B组ACR明显高于C组(P0.05)。(3)相关分析示d MAP、n MAP与SCR、SUA、ACR分别呈正相关,MBP与SCR、SUA、ACR分别呈负相关;ACR与BUN、SCR、SUA分别呈正相关(P0.05)。结论:子痫前期孕妇昼夜血压节律性多数呈"非杓型",血压升高水平及昼夜节律性改变与ACR、肾功能指标升高密切相关,ACR能反映尿蛋白的排泄及肾脏受损的程度。
[Abstract]:Objective: to investigate the characteristics of 24 h ambulatory blood pressure (ABBP) in preeclampsia pregnant women, and the relationship between the circadian blood pressure rhythm and urinary creatinine ratio (CRR) and renal dysfunction. Methods: 80 pregnant women with preeclampsia were collected and analyzed. According to the disease condition, 35 cases were divided into two groups: group A (35 cases) and group B (45 cases). 40 normal pregnant women with similar body weight were selected as control group C. All subjects were given 24 h ambulatory blood pressure monitoring (ABPM), and the characteristics and circadian rhythm of 24 h blood pressure were analyzed. ACR was detected by random sampling of urine in middle part of the study. The correlation between ABPM and random ABPM and renal function index in preeclampsia pregnant women were compared. Results the HR of 24 h SBPnSBPnDBPnMAPNMAPN MAPD MAPD MAPN HRN HR24 h in group A was significantly higher than that in group B (P 0.05N) and group B (MBP10), while in group B (group B), it was higher than that in group B (P 0.05) and in group B (group B), and in the daytime, it was found that in group B, it was higher than that in group B (P 0.05A) and in group B (group B). Nocturnal blood pressure was "non-dipper" in group A and group A had significantly higher serum BNU-SCRS-SUA and ACR than those in group B and group B, respectively. The correlation analysis showed that d MAPN MAP was significantly higher than that of group C (P0.05. 3) correlation analysis showed that there was a positive correlation between d MAPN MAP and SCRSUAACR. MBP was negatively correlated with ACR and BUNSCRSUAA was negatively correlated with BUNSCRSUA respectively (P < 0. 05, P < 0. 05, P < 0. 05); the correlation analysis showed that there was a positive correlation between d MAPN MAP and SCR SUAACR in group A (P < 0. 05). Conclusion: the circadian blood pressure rhythm of preeclampsia pregnant women is "non-dipper", and the elevation of blood pressure and the circadian rhythm are closely related to ACR.ACR can reflect the excretion of urine protein and the degree of renal damage.
【作者单位】：广东省惠州市第一妇幼保健院内科;
【分类号】：R714.244

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