前S1抗原与甲胎蛋白检测对妊娠期糖尿病孕妇HBV感染的研究

发布时间：2018-02-16 07:02

本文关键词： 甲胎蛋白妊娠期糖尿病乙型肝炎病毒感染　出处：《中华医院感染学杂志》2015年24期 　论文类型：期刊论文

【摘要】：目的分析乙型肝炎(HBV)前S1抗原(PreS1)、甲胎蛋白(AFP)检测对于妊娠期糖尿病(GDM)孕妇HBV感染的临床意义,为选择诊断和评价方法提供客观依据。方法选取2010年12月-2014年12月120例GDM合并HBV感染孕妇为研究对象,并根据其血清指标检测结果将其分为大三阳组58例和小三阳组62例,同期选取120例正常孕妇作为对照组;对比各组患者临床资料,数据采用SPSS 13.0软件进行统计分析。结果在不同孕期,大三阳组孕妇的血清HBV-DNA阳性率、血清Pre S1阳性率显著高于小三阳组及对照组,小三阳组的上述指标显著高于对照组(P0.05);多因素分析显示,孕妇的HBV-DNA表达量与血清Pre S1阳性率、血清AFP水平具有相关性(P0.05)。结论血清Pre S1阳性率、血清AFP水平与GDM合并HBV感染孕妇的病毒复制和传染性相关,可用于疾病的早期诊断与病情评价。
[Abstract]:Objective to analyze the clinical significance of HBV infection in pregnant women with hepatitis B hepatitis B virus (HBV) preS1 antigen preS1 and alpha-fetoprotein (AFP). Methods from December 2010 to December 2014, 120 pregnant women with GDM complicated with HBV infection were selected as the study objects, and were divided into three groups according to the results of serum test, including 58 cases in the Sanyang group and 62 cases in the group of small Sanyang group. In the same period, 120 normal pregnant women were selected as the control group, the clinical data of each group were compared and the data were analyzed by SPSS 13.0 software. The positive rate of serum Pre S1 was significantly higher than that of the small three positive group and the control group, and the above indexes of the small three positive group were significantly higher than that of the control group P0.05.The multivariate analysis showed that the expression of HBV-DNA and the positive rate of serum Pre S1 in pregnant women were significantly higher than those in the control group. Conclusion the positive rate of serum Pre S1 and serum AFP level are correlated with viral replication and infectivity of pregnant women infected with GDM and HBV, which can be used for the early diagnosis and evaluation of the disease.
【作者单位】：咸宁市通山县康泰医院检验科;赤壁市蒲纺医院检验科;赤壁市妇幼保健医院检验科;赤壁市人民医院检验科;
【基金】：湖北省科技局基金资助项目(20124827)
【分类号】：R714.256

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