无症状人类免疫缺陷病毒女性携带者子宫颈人乳头瘤病毒感染状况分析

发布时间：2018-02-21 02:36

本文关键词： 人类免疫缺陷病毒携带者无症状人乳头瘤病毒子宫颈上皮内病变子宫颈癌　出处：《中国妇产科临床杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的调查人乳头瘤病毒(human papilloma virus,HPV)感染在无症状人类免疫缺陷病毒(human immunodeficien cy virus,HIV)女性携带者和非HIV感染者中的发生率,为宫颈病变的预防及早期诊断提供依据。方法选择2015年10月首都医科大学附属北京地坛医院红丝带公益行动中106例无症状HIV女性携带者为研究组,并选取同期妇产科门诊309例非HIV感染者为对照组,两组均进行宫颈液基薄层细胞学(TCT)和HPV DNA检测,部分异常者行阴道镜检查和宫颈活检。结果研究组和对照组TCT异常率分别为32.1%(34/106)和5.8%(18/309),高危型HPV检出率分别为35.7%(30/84)和10.8%(19/176),其中多重感染率分别为19.0%(16/84)和7.4%(13/176)。研究组患者中,排在前五位的高危型HPV亚型分别为HPV52(8/32,25.0%)、HPV16(6/32,18.8%)、HPV18(5/32,15.6%)、HPV56(5/32,15.6%)、HPV66(5/32,15.6%),对照组为HPV16(5/23,21.7%)、HPV18(5/23,21.7%)、HPV58(4/23,17.4%)、HPV33(3/23,13.0%)、HPV56(3/23,13.0%)。两组联合HPV和TCT异常的检出率分别为44.0%(37/84)和15.9%(28/176)。研究组12例宫颈活检结果中,7例CIN1,3例CIN2,1例CIN3,1例宫颈微小浸润癌;对照组5例活检中,4例CIN1,1例CIN2。结论无症状HIV女性携带者感染HPV的风险显著高于非HIV感染者。无症状HIV携带者应视为HPV感染的高危人群。
[Abstract]:Objective to investigate the prevalence of human papilloma virus (HPV) infection in asymptomatic human immunodeficiency virus (immunodeficien) carriers and non-HIV infected women. Methods in October 2015, 106 asymptomatic female carriers of HIV in Beijing The Temple of Earth Hospital of Capital Medical University were selected as study group. In the same period, 309 patients with HIV infection in gynecology and obstetrics outpatient department were selected as control group. TCTs and HPV DNA were detected in both groups. Results the abnormal rates of TCT in the study group and the control group were 32.1% 34 / 106) and 5.88% / 309%, respectively. The detection rate of high-risk HPV was 35.710 / 84) and 10.8% 19 / 176%, respectively. The multiple infection rate was 19.01684) and 7.44mb / r 13176g in the study group. The high risk HPV subtypes in the top five were HPV52P / 8 / 32n 25.025.0 / HPV1666.32215.818.87.The detection rate of HPV565R / 3215.6r-1 / 3215.6m HPV665R / HPV1652323215.6A in the control group was HPV52232.77.The results showed that there were 7 cases of cervical cancer in the study group of 12 cases of HPV584 / 42317.4r.32313.00% HPV563.2313.00.The detection rates of HPV and TCT were 44.03784 and 915.2867 respectively. Conclusion the risk of HPV infection in asymptomatic HIV female carriers is significantly higher than that in non-#en2# infected women. Asymptomatic HIV carriers should be regarded as high risk groups for HPV infection.
【作者单位】：首都医科大学附属北京地坛医院病理科;
【分类号】：R737.33

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