血清Hcy水平最佳切点与早产危险因素关系及其Logistic回归分析

发布时间：2018-02-22 01:22

本文关键词： Hcy 早产危险因素 Logistic回归最佳切点　出处：《实用医学杂志》2017年19期 　论文类型：期刊论文

【摘要】：目的探讨血清同型半胱氨酸(Hcy)最佳切点选择与孕妇早产的关系,分析Hcy水平对早产儿结局影响。方法选择114例早产孕妇,103例正常产检孕妇为正常对照组,检测其Hcy、D-二聚体及超敏C反应蛋白;运用SPSS 13.0软件分析其ROC曲线,对早产危险因素进行多因素logistic回归分析。结果(1)早产孕妇组Hcy、HS-CRP以及D-二聚体水平高于正常对照组,差异有统计学意义(P0.05)。(2)Logistic回归分析得出Hcy水平相对危险系数(OR)为9.736,并获得早产概率回归方程。(3)应用ROC曲线评价Hcy在早产的危险因子中预测值0.931;当Hcy为13.8μmol/L时,其Youden指数为0.784。(4)早产孕妇Hcy水平升高会导致发生SGA可能性明显增加。结论在预测早产危险因素时,Hcy最佳预测切值是13.8μmol/L,是早产独立危险因素之一。
[Abstract]:Objective to investigate the relationship between the optimal point selection of serum homocysteine cysteine (HCH) and preterm delivery, and to analyze the effect of Hcy level on the outcome of preterm infants. Methods one hundred and four preterm pregnant women with normal birth test were selected as the normal control group. SPSS 13.0 software was used to analyze the ROC curve and multivariate logistic regression analysis of preterm labor risk factors. Results 1) the levels of Hcyn HS-CRP and D- dimer in preterm pregnant women were higher than those in normal controls. Logistic regression analysis showed that the relative risk coefficient of Hcy level was 9.736, and the regression equation of preterm probability was obtained. The ROC curve was used to evaluate the predictive value of Hcy in the risk factors of premature delivery, and when Hcy was 13.8 渭 mol/L, the predicted value of Hcy was 0.931. The increase of Hcy level in preterm pregnant women with a Youden index of 0.784.40% would result in a significant increase in the probability of SGA. Conclusion the best predicted shear value of Hcy is 13.8 渭 mol / L in predicting the risk factors of premature delivery, which is one of the independent risk factors for premature delivery.
【作者单位】：安徽医科大学附属宿州市立医院检验科;安徽医科大学附属宿州市立医院产科;
【基金】：国家863科技基金(编号:2014AA022304)
【分类号】：R446.1;R714.21

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