全部胚胎冷冻对不同促排卵方案患者临床应用的探讨

发布时间：2018-02-22 07:47

本文关键词： 冻融胚胎移植(FET) 短方案胚胎种植率妊娠率　出处：《中华生殖与避孕杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的分析不同超促排卵方案新鲜胚胎移植和冻融胚胎移植的临床妊娠结局,探讨全部胚胎冷冻技术在临床应用中的价值。方法回顾性分析行胚胎移植的525个周期患者的临床资料,其中253个周期为新鲜胚胎移植周期,272个周期为同期的复苏胚胎移植周期。纳入的促排卵方案包括促性腺激素释放激素激动剂(GnRH-a)长方案组(A组)和GnRH-a短方案组(B组)。分别比较两组中新鲜胚胎移植和冻融胚胎移植(FET)的妊娠结局,以及新鲜胚胎移植周期和复苏胚胎移植周期中2种方案妊娠结局。结果 A组中,新鲜胚胎移植周期(A1组)和FET周期(A2组)的临床妊娠率分别为45.95%和47.71%(P0.05);B组中,新鲜胚胎移植周期(B1组)和FET(B2组)的临床妊娠率分别为27.94%和46.30%(P0.05);A1组和B1组的受精率和可用胚胎率组间无统计学差异(P0.05),A组的平均获卵数、临床妊娠率和胚胎种植率显著高于B组(P0.05);A2组和B2组的临床妊娠率和胚胎种植率均无统计学差异(P0.05)。结论 FET并不能显著改善长方案患者的临床妊娠结局,但可显著提高短方案组的临床妊娠率,提示短方案患者可考虑采用全部胚胎冷冻。
[Abstract]:Objective to analyze the clinical pregnancy outcome of fresh embryo transfer and freeze-thawed embryo transfer in different superovulation schemes. Methods the clinical data of 525 cycles of embryo transfer were analyzed retrospectively. Of these, 253 cycles were fresh embryo transfer cycles and 272 cycles were resuscitation cycles. The ovulation promotion protocols included gonadotropin releasing hormone agonist GnRH-aA group (group A) and GnRH-a short regimen group (group B). The pregnancy outcomes of fresh embryo transfer and frozen thawed embryo transfer were compared between the two groups. Results the clinical pregnancy rates of group A (fresh embryo transfer cycle A1) and FET cycle A 2 (group A) were 45.95% and 47.71% respectively. The clinical pregnancy rates of FET(B2 group and fresh embryo transfer cycle group were 27.94% and 46.30, respectively. There was no significant difference in fertilization rate and available embryo rate between group A and group B1. The clinical pregnancy rate and embryo implantation rate in group B were significantly higher than those in group B (P 0.05) and group B2 (P 0.05). Conclusion FET can not significantly improve the clinical pregnancy outcome of patients with long term regimen. But the clinical pregnancy rate was significantly increased in the short regimen group, suggesting that all embryo cryopreservation could be considered in the short regimen group.
【作者单位】：枣庄市妇幼保健院生殖中心;
【基金】：山东省自然科学基金项目(2015ZRA04005)~~
【分类号】：R714.8

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