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牙周病与早产及低体质量儿关系的临床研究

发布时间:2018-02-22 09:09

  本文关键词: 牙周病 婴儿 早产 肿瘤坏死因子α 前列腺素E 基质金属蛋白酶 C反应蛋白 出处:《福建医科大学学报》2017年02期  论文类型:期刊论文


【摘要】:目的探讨孕妇牙周状况与早产及低体质量儿的关系。方法收集出现先兆早产的孕妇,选择其中出现早产或低体质量新生儿的孕妇50例为早产组,以同期来医院足月待产的孕妇50例为足月产组。所有产妇分娩前均进行全口牙周检查,记录菌斑指数(PLI)、牙石指数(CI)、牙龈出血指数(BI)、牙周探诊深度(PD)及临床附着丧失(CAL)。检测2组孕妇外周血中炎症相关细胞因子肿瘤坏死因子α、前列腺素E2、基质金属蛋白酶-9和C反应蛋白的水平。将分娩孕周及新生儿体质量、牙周状况和外周血细胞因子水平分别做相关性分析。结果与足月产组比较,早产组孕妇的牙周状况较差,PLI,BI,CI及牙周炎患病率均显著升高(P0.05);孕妇的PLI,BI,CI及牙周炎患病率与分娩孕周及新生儿体质量呈负相关。早产组外周血中炎症相关细胞因子水平均显著高于足月产组;孕妇外周血中细胞因子水平与PLI,BI,CI和牙周炎患病率呈正相关,与分娩孕周及新生儿体质量呈负相关。结论孕妇牙周状况与早产低体质量新生儿间可能存在一定的相关性;牙周状况对早产及低体质量儿的影响可能与外周血中炎症相关细胞因子的改变有关。
[Abstract]:Objective to investigate the relationship between periodontal status of pregnant women and premature delivery and low body weight infants. Methods 50 pregnant women with premature birth or low body weight newborn were selected as premature delivery group. A total of 50 pregnant women with full term labor in the hospital during the same period were selected as the term delivery group. All the pregnant women underwent periodontal examination before delivery. The plaque index, dental stone index, gingival bleeding index, periodontal probing depth and clinical attachment loss were recorded. The levels of inflammatory cytokines tumor necrosis factor 伪, prostaglandin E 2, matrix metalloprotein in peripheral blood of pregnant women in both groups were measured. Levels of enzyme -9 and C-reactive protein. The correlation between periodontal status and peripheral blood cytokine levels was analyzed. The prevalence of PLII-BICI and periodontitis in preterm pregnant women was significantly higher than that in pregnant women (P 0.05), and the prevalence of PLII-BICI and periodontitis in pregnant women was negatively correlated with maternal gestational weeks and neonatal body mass. Inflammatory cytokines in peripheral blood of preterm labor group. The average value was significantly higher than that in term group. The levels of cytokines in maternal peripheral blood were positively correlated with the prevalence of PLII-BICI and periodontitis, and negatively correlated with maternal gestational weeks and neonatal body mass. Conclusion there may be a certain correlation between maternal periodontal status and preterm low birth weight newborns. The effect of periodontal status on premature delivery and low body mass infants may be related to the changes of inflammatory cytokines in peripheral blood.
【作者单位】: 福建莆田学院附属医院口腔科;福建医科大学口腔医学院;南京大学医学院附属口腔医院高级专家诊疗科;
【分类号】:R714.2;R781.42

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