不同方案和移植前激素对移植解冻后生长胚胎妊娠结局的影响

发布时间：2018-02-22 13:38

本文关键词： 冻融胚胎移植自然周期激素替代周期活产率　出处：《中国现代医学杂志》2016年23期 　论文类型：期刊论文

【摘要】：目的探讨在冷冻胚胎复苏移植周期中,解冻后过夜培养均生长的胚胎在两种内膜准备方案移植,影响妊娠结局的因素分析。方法选取在该中心行冻融胚胎移植的患者305例,359个周期的病历资料为研究对象,并对其进行回顾性分析。冷冻胚胎解冻后观察胚胎生长情况,其中胚胎均有不同程度生长为生长组(191例),胚胎均未见生长的为未生长组(48例),胚胎既有生长的又含有未生长的为生长混合组(120例)。其中生长组按照不同内膜准备方案将其分类,分为自然周期组(90例)和激素替代治疗周期组(101例)。比较各组的妊娠率、种植率、流产率、活产率的差别。结果生长组种植率为26.57%,高于生长混合组的16.78%(χ2=9.135,P=0.002)。自然周期组和激素替代治疗周期组移植前雌二醇、孕酮比较,差异有统计学意义(t=12.392和3.667,P=0.000和0.006)。在临床助孕结局方面,自然周期组和激素替代治疗周期组的临床妊娠率、种植率、异位妊娠率等比较,差异无统计学意义;而两组流产率、活产率比较,差异有统计学意义(χ2=3.949和5.991,P=0.044和0.020)。结论胚胎解冻后经过夜培养,有卵裂球细胞生长的胚胎能够获得较高的种植率和妊娠率,且移植均生长发育的胚胎在自然周期方案有较好的妊娠结局。
[Abstract]:Objective to explore two kinds of endomembrane preparation schemes for embryo growth after thawing during the period of frozen embryo resuscitation transfer. Methods 305 cases (359 cycles) of frozen-thawed embryo transfer in the center were selected and analyzed retrospectively. The embryo growth was observed after thawing. Among them, there were 191 cases of growth group, 48 cases of non-growth group and 120 cases of non-growth mixed group. The standby scheme classifies it, They were divided into natural cycle group (n = 90) and hormone replacement therapy group (n = 101). The pregnancy rate, implantation rate and abortion rate were compared. Results the planting rate of the growth group was 26.57, which was higher than that of the mixed growth group (蠂 2 9.135 P0. 002). The difference of estradiol and progesterone between the natural cycle group and the hormone replacement therapy cycle group was statistically significant. There was no significant difference in clinical pregnancy rate, implantation rate, ectopic pregnancy rate between natural cycle group and hormone replacement therapy cycle group, but there was no significant difference between the two groups in abortion rate and live birth rate. The difference was statistically significant (蠂 2, 3.949, 5.991P 0.044 and 0.020, respectively). Conclusion after thawing, embryos with blastomere growth can obtain higher implantation rate and pregnancy rate. And all the embryos transplanted have good pregnancy outcome in the natural cycle scheme.
【作者单位】：内蒙古医科大学附属医院生殖中心;
【基金】：内蒙古医科大学科技百万工程(No:YKD2015KJBW023) 内蒙古自治区高等学校科学研究项目(No:NJZY16118)
【分类号】：R714.8

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