ER、PR和p53在老年子宫内膜癌患者中的表达及意义

发布时间：2018-02-23 22:21

本文关键词： 子宫内膜癌雌激素受体孕激素受体 p　出处：《中国老年学杂志》2015年21期 　论文类型：期刊论文

【摘要】：目的探讨雌激素受体(ER)、孕激素受体(PR)和p53在老年子宫内膜癌患者中的表达及意义。方法采用免疫组织化学Envision法检测21例老年子宫内膜癌(老年组)与40例非老年子宫内膜癌(非老年组)患者中ER、PR和p53蛋白的表达。结果 ER、PR、p53阳性率在老年组和非老年组中分别为71.4%、76.2%、81%和77.5%、90%、57.5%,PR表达在两组间有显著性差异(P=0.036)。p53阳性表达与年龄呈正相关(r=0.279,P=0.029)。结论 PR和p53在不同年龄子宫内膜癌中的表达差异与肿瘤生物学行为及预后有一定关系。老年患者的PR表达较非老年患者显著降低,而这会影响两组人群孕激素的治疗效果。
[Abstract]:Objective to investigate the expression and significance of estrogen receptor ERA, progesterone receptor PRI and p53 in elderly patients with endometrial carcinoma. Methods Immunohistochemical Envision method was used to detect 21 cases of elderly endometrial carcinoma (elderly group) and 40 cases of non-elderly endometrial carcinoma. The expression of ERP PR and p53 protein in endometrial carcinoma (non-elderly group). Results the positive rate of ERP PRN p53 was 71. 4% in elderly group and 76. 2% in non-elderly group, respectively. There was a significant difference between the two groups in the expression of ERP PR and P 0. 036. P53. P53 expression was positively correlated with age. Conclusion the difference between the expression of PR and p53 in endometrial carcinoma of different ages is related to tumor biological behavior and prognosis. The expression of PR in elderly patients is significantly lower than that in non-elderly patients. This will affect the treatment of progesterone in both groups.
【作者单位】：同济大学附属第十人民医院妇产科;同济大学附属第十人民医院病理科;
【基金】：国家自然科学基金(81202045)
【分类号】：R737.33

【共引文献】