DNA修复基因XRCC3多态性与卵巢癌相关性研究的meta分析

发布时间：2018-02-25 01:18

本文关键词： XRCC基因单核苷酸多态性卵巢癌易感性 meta分析　出处：《上海交通大学学报(医学版)》2015年05期 　论文类型：期刊论文

【摘要】：目的研究DNA修复基因XRCC3的3种单核苷酸多态性(T241M、A4541G和A17893G)各自与卵巢癌易感性的关系并进行meta分析。方法计算机全面检索数据库中相关文献,收集有关XRCC3基因多态性(T241M、A4541G和A17893G)与卵巢癌发病相关的病例对照研究,按照纳入文献质量评价标准,剔除不符合要求的文献,应用Stata 10.0软件计算OR及其95%CI,对各研究结果进行数据合并,比较XRCC3不同基因型以及基因多态性与卵巢癌易感性的关系,并检验一致性和评估发表偏倚。结果纳入6项研究进行meta分析,包括卵巢癌病例组5 529例,对照组8 350例,均符合H-W遗传平衡。meta分析结果表明XRCC3 T241M中T和M等位基因、XRCC3 A4541G中A和G等位基因、XRCC3 A17893G中A和G等位基因在病例组和对照组的频率分布比较,差异均无统计学意义(P0.05)。XRCC3 T241M多态性与卵巢癌的发生风险均无明显相关(P0.05)。XRCC3 A4541G基因多态性与卵巢癌发病风险相关,其中GG/AA、GG/AG+AA、AG/AA基因型与卵巢癌发病风险相关(P0.05;OR=0.71,95%CI=0.56~0.90;OR=0.67,95%CI=0.53~0.87;OR=1.06,95%CI=1.00~1.14)。XRCC3 A17893G基因多态性与卵巢癌的发病风险相关,其中GG+AG/AA和GG/AG+AA基因型与卵巢癌发病风险相关(P0.05;OR=0.81,95%CI=0.79~0.84;OR=1.14,95%CI=1.02~1.28)。结论 XRCC3 A4541G和A17893G基因多态性与卵巢癌发病风险相关。
[Abstract]:Objective to study the relationship between three single nucleotide polymorphisms (SNP) of DNA repair gene XRCC3 and susceptibility to ovarian cancer, and to analyze their relationship with susceptibility to ovarian cancer. A case-control study on the association of XRCC3 gene polymorphisms T241MU A4541G and A17893G with the incidence of ovarian cancer was collected. Stata 10.0 software was used to calculate OR and 95 CI.The data of each study were combined to compare the relationship between XRCC3 genotypes and gene polymorphisms and susceptibility to ovarian cancer. Results meta analysis was performed in 6 studies, including 5 529 cases of ovarian cancer and 8 350 cases of control group. The results of H-W genetic balance and meta analysis showed that the frequencies of A and G alleles in XRCC3 A4541G of XRCC3 T241m were compared with those of XRCC3 A17893G in case group and control group. There was no significant difference between the polymorphism of P0.05N. XRCC3 T241M and the risk of ovarian cancer. There was no significant correlation between the polymorphism of P0.05N. XRCC3 A4541G gene and the risk of ovarian cancer. Among them, the genotype of GG / AG / AAG / AA was associated with the risk of ovarian cancer (P 0.05). The risk of ovarian cancer was associated with the genetic polymorphisms of 0.560.90 ~ (0.90) ~ (0.70) ~ (95) ~ 0.53 ~ 0.87 ~ (th) ~ 1.00 ~ 1.14. XRCC3 A17893G gene polymorphism and the risk of ovarian cancer. The genotype of GG AG/AA and GG/AG AA was associated with the risk of ovarian cancer. Conclusion the polymorphism of XRCC3 A4541G and A17893G gene is associated with the risk of ovarian cancer.
【作者单位】：上海交通大学医学院附属瑞金医院妇产科;
【分类号】：R737.31

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