宫颈部人乳头瘤病毒高危型感染状况及基因亚型分析

发布时间：2018-02-25 17:45

本文关键词： 人乳头瘤病毒基因型宫颈癌　出处：《中国皮肤性病学杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的调查宫颈部人乳头瘤病毒(HPV)高危型感染情况及其基因亚型分析,为HPV感染分子流行病学研究及宫颈癌防治提供依据。方法采用凯普导流杂交HPV DNA检测法,对疑似HPV感染的1 585例宫颈脱落细胞进行21种HPV亚型检测;并对高危型HPV阳性患者进行薄层液基细胞学检查(TCT)和病理活检。结果 1 585例标本中有414例HPV检测阳性,感染率为26.12%,其中高危型占82.61%,单一高危亚型感染占83.33%,其主要基因亚型是52,16和38,检出频率分别26.57%,25.60%和13.29%;HPV高危型感染率随着年龄的增长而升高,21岁除外;342例高危型HPV阳性患者中有38例液基薄层细胞学检查阳性,33例病理活检阳性。结论 1 585例中宫颈部人乳头瘤病毒高危型感染较严重,以单一高危亚型感染为主,HPV52,16和38是其中的主要高危亚型。
[Abstract]:Objective to investigate the high risk type infection of human papillomavirus (HPV) and its gene subtype analysis, and to provide the basis for the molecular epidemiology of HPV infection and the prevention and treatment of cervical cancer. 21 HPV subtypes were detected in 1 585 cervical exfoliated cells suspected of HPV infection. Thin-layer liquid-based cytology and pathological biopsy were performed in high-risk HPV positive patients. Results 414 of 1 585 specimens were positive for HPV. The infection rate was 26.12, including high risk type (82.61) and single high risk subtype (83.33). The main gene subtypes were 52an16 and 38, respectively. The detection frequencies were 26.57% and 13.29%, respectively. The positive rate of high-risk HPV was increased with age in 342 cases except 21 years of age. Among the 38 patients, 38 cases were positive for fluid based thin layer cytology and 33 cases were positive for pathological biopsy. Conclusion the high risk type infection of human papillomavirus in the neck of uterus is more serious in 1 585 cases. HPV52A16 and 38 were the main high risk subtypes of single high risk subtype infection.
【作者单位】：南方医科大学附属小榄医院检验科及病理科;
【分类号】：R737.33

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