左炔诺孕酮宫内释放系统对IGF-1的影响及预防盆腔炎疗效分析

发布时间：2018-02-26 19:30

本文关键词： 子宫内膜息肉子宫内膜息肉电切术左炔诺孕酮宫内释放系统盆腔炎胰岛素样生长因子-　出处：《湖南师范大学学报(医学版)》2016年06期 　论文类型：期刊论文

【摘要】：目的 :左炔诺孕酮宫内释放系统对IGF-1的影响及预防盆腔炎疗效分析。方法 :选取2014年1月~2015年11月在我院住院治疗的子宫内膜息肉患者130例,根据术后治疗药物随机分为左炔诺孕酮宫内释放系统治疗组(观察组)和去氧孕烯炔雌醇片治疗组(对照组),比较两组患者治疗前后月经量和子宫内膜厚度、子宫内膜IGF-1表达、以及盆腔炎发生率的差异。分析盆腔炎发生与子宫内膜IGF-1表达的关系,分析子宫内膜厚度与子宫内膜IGF-1表达的关系。结果 :治疗后观察组患者的月经量(33.57±15.62)ml、子宫内膜厚度(6.12±0.85)mm均低于对照组(52.85±15.39)ml和(8.52±0.91)mm,且差异均具有统计学差异;治疗后观察组患者的腺皮质和间质IGF-1表达(1.41±0.74)和(1.36±0.72)均低于对照组(1.75±0.82)和(1.72±0.83),且差异均具有统计学差异;观察组盆腔炎的发生率(6例,9.23%)低于对照组(17例,26.15%),且差异具有统计学差异;治疗后发生盆腔炎的患者腺皮质和间质IGF-1表达(1.58±0.81)和(1.62±0.75)均高于未发生盆腔炎者(1.22±0.71)和(1.32±0.75),且差异均具有统计学差异;子宫内膜厚度与腺皮质IGF-1表达呈正相关,与间质IGF-1表达呈正相关。结论 :左炔诺孕酮宫内释放系统能明显减少子宫内膜息肉患者术后盆腔炎的发生率好改善其临床症状,可能因为药物抑制了子宫内膜增生和IGF-1表达从而减少盆腔炎的发生。
[Abstract]:Objective: to analyze the effect of levonorgestrel intrauterine release system on IGF-1 and the effect of preventing pelvic inflammation. Methods: 130 patients with endometrial polyps who were hospitalized in our hospital from January 2014 to November 2015 were selected. The patients were randomly divided into two groups: levonorgestrel intrauterine release system treatment group (observation group) and deoxypregnenes estradiol treatment group (control group). The menstrual volume, endometrial thickness and endometrial IGF-1 expression were compared between the two groups before and after treatment. And the difference in the incidence of pelvic inflammatory disease. To analyze the relationship between the occurrence of pelvic inflammatory disease and the expression of IGF-1 in endometrium, The relationship between endometrial thickness and endometrial IGF-1 expression was analyzed. Results: after treatment, the menstrual volume and endometrial thickness in the observation group were 33.57 卤15.62ml and 6.12 卤0.85mm, respectively, which were lower than those in the control group (52.85 卤15.39ml and 8.52 卤0.91mm. respectively). After treatment, the expression of IGF-1 in glandular cortex and stroma in the observation group was 1.41 卤0.74) and 1.36 卤0.72 卤0.72 卤0.72), which was significantly lower than that in the control group (1.75 卤0.82) and 1.72 卤0.83%, and the incidence of pelvic inflammation in the observation group (6 cases) was lower than that in the control group (17 cases), and the difference was statistically significant. The expression of IGF-1 in glandular cortex and stroma of patients with pelvic inflammatory disease after treatment was 1.58 卤0.81) and 1.62 卤0.75), which was significantly higher than that in patients without pelvic inflammatory disease (1.22 卤0.71) and 1.32 卤0.75.There was a positive correlation between endometrial thickness and IGF-1 expression in glandular cortex. Conclusion: levonorgestrel intrauterine release system can significantly reduce the incidence of pelvic inflammatory disease in patients with endometrial polyps and improve their clinical symptoms. It may be that drugs inhibit endometrial hyperplasia and IGF-1 expression, thereby reducing the incidence of pelvic inflammatory disease.
【作者单位】：延安大学附属医院妇科二病区;
【分类号】：R711.33;R713.4

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