卵巢透明细胞癌中HNF-1β的诊断价值

发布时间：2018-02-28 11:34

本文关键词： 卵巢肿瘤透明细胞癌 HNF-β 免疫组织化学　出处：《临床与实验病理学杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的观察HNF-1β在卵巢不同类型上皮性癌中的表达,探讨HNF-1β在卵巢透明细胞癌诊断中的价值。方法采用免疫组化En Vision法检测27例透明细胞癌、35例高级别浆液性癌、21例子宫内膜样腺癌、10例黏液性癌、2例移行细胞癌和13例转移性Krukenberg瘤中HNF-1β的表达。结果 27例卵巢透明细胞癌均不同程度表达HNF-1β,阳性率为85.2%;35例卵巢高级别浆液性癌中HNF-1β呈核阳性者4例,阳性率为2.9%;21例卵巢子宫内膜样腺癌中5例HNF-1β呈阳性,阳性率为23.8%;10例卵巢黏液性癌中HNF-1β均呈核阳性,阳性率为60.0%;13例Krukenberg瘤均可见HNF-1β呈不同程度核阳性,阳性率为53.8%;2例卵巢移行细胞癌均不表达HNF-1β。与透明细胞癌相比,HNF-1β在浆液性癌和子宫内膜样腺癌中的表达降低,差异有统计学意义(P0.01)。黏液性癌、Krukenberg瘤和透明细胞癌中HNF-1β表达差异均无显著性(P0.05)。HNF-1β诊断卵巢透明细胞癌的敏感性和特异性分别为85.2%和76.5%。结论 HNF-1β是一种敏感性较高的卵巢透明细胞癌标志物,HNF-1β弥漫强阳性对诊断卵巢透明细胞癌具有较高的特异性。
[Abstract]:Objective to investigate the expression of HNF-1 尾 in different types of epithelial ovarian carcinoma. To investigate the value of HNF-1 尾 in the diagnosis of ovarian clear cell carcinoma. Methods Immunohistochemical en Vision method was used to detect 35 cases of high grade serous carcinoma of 27 cases of clear cell carcinoma and 21 cases of endometrial adenocarcinoma 10 cases of mucinous carcinoma and 2 cases of transitional cell carcinoma; Results HNF-1 尾 was expressed in all 27 cases of ovarian clear cell carcinoma, and the positive rate was 85.2% in 35 cases of ovarian high grade serous carcinoma. The positive rate of HNF-1 尾 was positive in 5 of 21 cases of ovarian endometrioid adenocarcinoma. The positive rate was 23.810 cases of ovarian mucinous carcinoma. The positive rate of HNF-1 尾 was nuclear positive in all the 13 cases of Krukenberg tumor, and the positive rate was 60.010 cases of ovarian mucinous carcinoma. The positive rate was 53.8% and 2 cases of ovarian transitional cell carcinoma did not express HNF-1 尾. Compared with clear cell carcinoma, the expression of HNF-1 尾 in serous carcinoma and endometrial adenocarcinoma was decreased. There was no significant difference in the expression of HNF-1 尾 between mucinous carcinoma Krukenberg tumor and clear cell carcinoma. The sensitivity and specificity of HNF-1 尾 in the diagnosis of ovarian clear cell carcinoma were 85.2% and 76.5g respectively. Conclusion HNF-1 尾 is a highly sensitive egg. HNF-1 尾 diffusely positive is a specific marker for the diagnosis of ovarian clear cell carcinoma.
【作者单位】：南京医科大学附属南京医院(南京市第一医院)病理科;南京医科大学附属南京妇幼保健院病理科;
【分类号】：R737.31

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