MMP-2和TIMP-2在宫腔粘连患者子宫内膜中的表达

发布时间：2018-03-01 00:15

本文关键词： 宫腔粘连 MMP-2 TIMP-2 免疫组化　出处：《中南大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：探讨宫腔粘连(intrauterine adhesions, IUA)患者子宫内膜组织中基质金属蛋白酶2(MMP-2)与基质金属蛋白酶抑制剂2(TIMP-2)的表达及其与IUA的相关性。方法：用免疫组织化学方法分别检测60例IUA患者及20例非IUA患者子宫内膜组织中MMP-2与TIMP-2的表达。结果：1、MMP-2在IUA患者子宫内膜组织中的表达低于对照组,两组比较差异有统计学意义(P0.05):TIMP-2在IUA患者子宫内膜组织中的表达高于对照组,两组比较差异有统计学意义(P0.05)。2、MMP2在重度IUA患者子宫内膜组织中的表达低于中度IUA患者(P0.05),在中度IUA患者子宫内膜组织中的表达低于轻度IUA患者(P0.05)。3、TIMP-2在重度IUA患者子宫内膜组织中的表达高于中度IUA患者(P0.05),在中度IUA患者子宫内膜组织中的表达高于轻度IUA患者(P0.05)。4、MMP-2与TIMP-2在IUA患者子宫内膜中的表达呈负相关(r=-0.727,P0.05)。结论：1、MMP-2和TIMP-2可能与宫腔粘连的形成有关。2、MMP-2表达的减弱和TIMP-2表达的增强可能与宫腔粘连的严重程度有关。
[Abstract]:Aim: to investigate the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase inhibitor 2 (TIMP 2) in endometrium of patients with intrauterine adhesion (IUAA) and their correlation with IUA. Methods: the expression of MMP-2 and TIMP-2 in endometrial tissues of 60 patients with IUA and 20 patients with non IUA were detected by immunohistochemistry. Results the expression of MMP 2 in endometrial tissue of IUA patients was lower than that of control group. The difference between the two groups was statistically significant (P 0.05% TIMP-2 expression was higher in endometrium tissue of IUA patients than that in control group). There was a significant difference between the two groups in the expression of P0.05MMP2 in endometrial tissues of severe IUA patients and in moderate IUA patients. The expression of P0.05MMP2 in endometrial tissues of moderate IUA patients was lower than that of mild IUA patients. 3TIMP-2 expression in the uterus of severe IUA patients was lower than that of moderate IUA patients. The expression of MMP-2 in the membrane tissue was higher than that in the moderate IUA group, and the expression of MMP-2 in the endometrial tissue of the moderate IUA group was higher than that in the mild IUA patient. There was a negative correlation between the expression of MMP-2 and TIMP-2 in the endometrium of IUA patients. Conclusion the decrease of MMP-2 expression and the increase of TIMP-2 expression may be related to the severity of intrauterine adhesions.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.74

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