腹腔镜下子宫肌瘤手术对人体氧化应激及肿瘤组织中基质金属蛋白酶表达的影响

发布时间：2018-03-02 01:30

本文关键词： 子宫肌瘤腹腔镜脂质过氧化基质金属蛋白酶　出处：《中国内镜杂志》2015年05期 　论文类型：期刊论文

【摘要】：目的分析腹腔镜下子宫肌瘤手术对人体氧化应激及肿瘤组织中基质金属蛋白酶(MMPs)表达的影响。方法选择在该院接受手术治疗的子宫肌瘤患者作为研究对象,随机分为接受开腹手术的对照组和接受腹腔镜手术的观察组,比较两组患者的蛋白与脂质氧化指标、抗氧化指标及肿瘤组织中MMPs表达的差异。结果观察组患者的术后血浆丙二醛(MDA)及晚期氧化蛋白产物(AOPP)等氧化指标水平明显低于对照组(P0.05)。观察组患者的术后血浆谷胱甘肽过氧化物酶(GSH-Px)及血浆总抗氧化能力(AOA)等抗氧化指标水平明显低于对照组(P0.05)。观察组子宫肌瘤组织中MMP-2、MMP-9蛋白和m RNA水平均低于对照组(P0.05)。结论腹腔镜下子宫肌瘤手术可以降低术后机体氧化应激反应,降低肿瘤组织MMPs表达。
[Abstract]:Objective to analyze the effect of laparoscopic hysteromyoma surgery on oxidative stress and the expression of matrix metalloproteinase (MMPs) in human tumor tissues. The patients were randomly divided into two groups: the control group undergoing laparotomy and the observation group undergoing laparoscopic surgery. The protein and lipid oxidation indexes were compared between the two groups. Results the levels of plasma malondialdehyde (MDA) and advanced oxidized protein (AOPP) were significantly lower in the observation group than in the control group (P 0.05). The postoperative plasma gluten of the patients in the observation group was significantly lower than that in the control group. The levels of GSH-Px) and plasma total antioxidant capacity (AOAA) were significantly lower than those of the control group (P0.05A). The levels of MMP-2MMP 9 and m RNA in uterine leiomyoma in the observation group were lower than those in the control group (P 0.050.Conclusion Laparoscopic hysteromyoma is lower than that in the control group (P 0.05). Surgery can reduce the oxidative stress response of the body after operation. The expression of MMPs in tumor tissue was decreased.
【作者单位】：河南科技大学第一附属医院妇产科;
【分类号】：R737.33

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