外阴富于细胞性血管纤维瘤1例报告并文献复习

发布时间：2018-03-02 03:02

本文关键词： 富于细胞性血管纤维瘤病理免疫组化　出处：《中国实用妇科与产科杂志》2015年06期 　论文类型：期刊论文

【摘要】：目的探讨外阴富于细胞性血管纤维瘤(CAF)的临床病理特征、鉴别诊断以及诊治方法和预后。方法选择2014-11-04中国医科大学附属盛京医院收治的1例外阴富于细胞性血管纤维瘤的病例,进行临床特点、组织形态学、免疫组织化学研究。结合文献分析本病的临床表现、病理形态特点及鉴别诊断。结果富于细胞性血管纤维瘤呈不规则小叶状,瘤细胞呈短梭形、大小一致、核卵圆至梭形、核分裂象不易见。肿瘤含大量的小至中等大小的血管,以无分支的毛细血管为主。病理切片特点为疏松排列的梭形细胞、脂肪瘤样细胞和突出的厚壁血管。免疫组织化学:肿瘤细胞Vimentin阳性,CD34阳性。CD31、SMA、S-100、HMB-45均阴性。结论富于细胞性血管纤维瘤是一种极少见的特殊的外阴部良性软组织肿瘤,肿瘤可能存在间质细胞增生活性不同的组织学亚型。治疗以手术为主,术后需严密复查。
[Abstract]:Objective to investigate the clinicopathological features, differential diagnosis, diagnosis and treatment and prognosis of vulvar hemangiofibroma (CAF). Methods one case of cytosolic angiofibroma was selected from Shengjing Hospital affiliated to China Medical University from 2014-11-04. The clinical features, histomorphology and immunohistochemistry were studied. The clinical manifestations, histopathologic features and differential diagnosis of the disease were analyzed. Results Cytoangiofibroma presented irregular lobular shape and short fusiform tumor cells. The tumor contains a large number of small to medium sized blood vessels, mainly non-branched capillaries. The pathological sections are characterized by loosely arranged spindle cells. Immunohistochemistry: tumor cells were Vimentin positive and CD34 positive. CD31 SMAS-100 HMB-45 was negative. Conclusion Cytoangiofibroma is a rare and special benign soft tissue tumor of the vulva. The tumor may have histological subtypes with different stromal cell proliferation activity.
【作者单位】：中国医科大学附属盛京医院妇产科;
【基金】：盛京自由研究者计划(201303)
【分类号】：R737.3

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