甲状腺过氧化物酶抗体阴性的妊娠期亚临床甲状腺功能减退症对妊娠结局及新生儿的影响

发布时间：2018-03-02 09:49

本文关键词： 甲状腺功能减退症妊娠结局新生儿　出处：《中国妇幼保健》2016年24期 　论文类型：期刊论文

【摘要】：目的探讨甲状腺过氧化物酶阴性的妊娠期亚临床甲状腺功能减退症(SCH)对妊娠结局及新生儿的影响。方法将60例诊断为SCH且甲状腺过氧化物酶抗体(TPOAb)阴性的妊娠期妇女随机分为左甲状腺素治疗组和非治疗组,每组30例。记录妊娠期高血压疾病(HDCP)、妊娠期糖尿病(GDM)、早产、流产、顺产发生率及新生儿Apgar评分和脐带血游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平,选取同期30例正常孕妇及新生儿为对照组,对相应指标进行比较分析。结果非治疗组HDCP、早产及流产发生率和新生儿脐带血TSH水平明显高于治疗组及对照组(P0.05),顺产率明显低于治疗组及对照组(P0.05),GDM发生率及新生儿Apgar评分与其他两组比较差异无统计学意义(P0.05)。治疗组与对照组比较,上述各种指标比较差异均无统计学意义(P0.05)。结论 TPOAb阴性的妊娠期SCH可导致不良妊娠结局,对新生儿产生不良影响;及时筛查并进行干预治疗可使孕妇及新生儿获益。
[Abstract]:Objective to investigate the effect of thyroid peroxidase negative hypothyroidism in pregnancy on pregnancy outcome and neonatal outcome. Methods 60 cases of SCH with thyroid peroxidase antibody negative in pregnancy were studied. Women were randomly divided into levothyroxine treatment group and non-treatment group. The incidence of gestational hypertension, gestational diabetes mellitus (GDM), premature delivery, abortion, spontaneous delivery and neonatal Apgar scores, free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH) levels were recorded in each group. 30 normal pregnant women and newborns were selected as control group. Results the incidence of HDCP, preterm delivery and miscarriage and the level of TSH in umbilical cord blood in the non-treatment group were significantly higher than those in the treatment group and control group (P 0.05), and the rate of spontaneous delivery was significantly lower than that in the treatment group and the control group. There was no significant difference in Apgar score between the two groups (P 0.05). Conclusion TPOAb negative pregnancy SCH can lead to adverse pregnancy outcome and have adverse effects on newborns, and timely screening and intervention treatment can benefit pregnant women and newborns.
【作者单位】：吉林大学中日联谊医院内分泌科;吉林大学中日联谊医院妇产科;
【分类号】：R714.256

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