Uu及其亚群、Mg感染与BV的相关性研究

发布时间：2018-03-03 05:11

本文选题：细菌性阴道病　切入点：解脲支原体　出处：《现代妇产科进展》2015年02期 　论文类型：期刊论文

【摘要】：目的:探讨细菌性阴道病(BV)与解脲支原体(Uu)及其parvo生物群和T960生物群、生殖支原体(Mg)的相关性。方法:随机采集2008年7月至12月在天津医科大学总医院妇科门诊就诊以Nugent法确诊的44例BV患者(BV组)和88例正常体检人群(对照组)的阴道盥洗液,应用real-time PCR法分别对Uu、parvo、T960和Mg进行DNA定量测定。结果:BV组和对照组的Uu检出率分别为65.9%和50%(P=0.060),其中parvo生物群检出率分别为47.7%和43.2%(P=0.378)。BV组的T960生物群检出率(22.7%)显著高于对照组(9.1%)(P=0.032)。两组的Mg检出率均为4.5%(P=1.000)。结论:(1)总体检测Uu可能与BV无相关性,但Uu的不同分群与BV相关性不同,Uu的parvo生物群可能是下生殖道的定植菌群,与BV发病无相关性;Uu的T960生物群与BV的发病存在相关性,可能参与BV的致病。对BV复发者应注意合并Uu的T960亚群感染的可能;(2)Mg感染可能与BV发病无相关性。
[Abstract]:Objective: to study the parvo and T960 biota of bacterial vaginosis (BV) and Ureaplasma Urealyticum (UU). Methods: from July 2008 to December, 44 patients with BV diagnosed by Nugent and 88 healthy people (control group) were randomly collected from gynecological outpatient clinic of Tianjin Medical University. Real-time PCR method was used to determine the DNA content of T960 and mg respectively. Results the detection rates of UU in the two groups were 65.9% and 50, respectively. The detection rates of parvo biota were 47.7% and 43.2%, respectively. The detection rate of T960 biota in the BV group was significantly higher than that in the control group (22.7%). The detection rate of mg in both groups was 4.5 and 1.0000.Conclusion the total detection of UU may have no correlation with BV. However, the parvo biota of UU with different correlation with BV may be the colonization of the lower reproductive tract, and the T960 biota of UU has no correlation with the pathogenesis of BV. It may be involved in the pathogenesis of BV. In patients with BV recurrence, the possibility of T960 subgroup infection associated with UU may not be associated with BV.
【作者单位】：天津医科大学总医院妇科;
【分类号】：R711.3

【参考文献】