肌动蛋白清除系统与凝血—纤溶系统在子痫前期患者外周血中的变化

发布时间：2018-03-04 07:22

本文选题：凝溶胶蛋白　切入点：维生素D结合蛋白　出处：《中国医科大学学报》2015年10期 　论文类型：期刊论文

【摘要】：目的探讨子痫前期患者外周血中凝溶胶蛋白(GSN)、游离维生素D结合蛋白(VDBP)及凝血—纤溶指标的变化与子痫前期发生发展的关系。方法选取子痫前期重度(SPE)、轻度(MPE)患者各30例、同孕龄健康孕妇(对照组1)和足月健康孕妇(对照组2)各30例,比较4组外周血中血浆GSN和游离VDBP的水平,以及凝血指标血小板(PLT)、凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-dimer)的水平。结果 MPE和SPE组中GSN、VDBP及PLT、PT、APTT、FIB的含量均明显低于对照组1(P0.05),D-dimer明显高于对照组1(P0.05)。SPE组中GSN、VDBP及PLT、PT、APTT、FIB的含量明显低于MPE组(P0.05),D-dimer明显高于MPE组(P0.05)。在健康孕妇中,对照组1与对照组2相比,随着孕周的增加,GSN水平呈下降趋势,VDBP水平呈上升趋势,均无统计学差异(P0.05),同时凝血指标均无统计学差异(P0.05)。结论子痫前期患者外周血中GSN、VDBP水平较健康孕妇显著降低,血液呈病理性高凝状态,且随着病情加重变化更为明显,与孕周关系不大。
[Abstract]:Objective to investigate the relationship between the changes of GSNN, VDBP and coagulation / fibrinolysis in peripheral blood of preeclampsia patients and the development of preeclampsia. Methods 30 patients with severe preeclampsia and 30 patients with mild preeclampsia were selected. The levels of plasma GSN and free VDBP in peripheral blood were compared in 30 healthy pregnant women of the same gestational age (control group 1) and 30 full-term healthy pregnant women (control group 2). The levels of thromboplastin, prothrombin time (PTT), activated partial thromboplastin time (APTTT), thrombin time (TTT), fibrinogen FIBB D- dimer (D-dimer) in MPE and SPE groups were significantly lower than those in control group. The levels of GSNV DBP and PLT PPTT APTTTIB in group 1 were significantly higher than those in group 1 (P 0 05), and the levels of D-dimer in group 1 (P 0. 05) were significantly higher than those in group 1 (P 0. 05). In healthy pregnant women, the levels of GSNN VDBP and PLTX PTT were significantly lower than those of MPE group (P 0. 05). Compared with control group 2, the level of GSN in control group 1 decreased and VDBP increased with the increase of gestational age. There was no significant difference in blood coagulation parameters (P 0.05). Conclusion the level of GSN-VDBP in peripheral blood of preeclampsia patients was significantly lower than that of healthy pregnant women, and the blood was in a pathological hypercoagulable state, and the changes were more obvious with the exacerbation of the disease. It has little to do with gestational age.
【作者单位】：中国医科大学附属盛京医院妇产科;
【分类号】：R714.245

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