孤立性鼻骨发育异常预测21-三体胎儿

发布时间：2018-03-04 23:19

本文选题：胎儿　切入点：染色体　出处：《中国医学影像技术》2015年01期 　论文类型：期刊论文

【摘要】：目的评估孤立性鼻骨发育异常预测21-三体胎儿的价值。方法回顾性分析产前诊断发现的32胎鼻骨发育异常胎儿,孕11~32周。将32胎鼻骨异常胎儿分为两组,孤立性鼻骨发育异常组(21胎)和非孤立性鼻骨发育异常组(即同时合并其他系统异常,11胎)。采用Fisher确切概率法比较两组间21-三体的发生率。结果孤立性鼻骨发育异常组21胎染色体结果均正常;非孤立性鼻骨发育异常组11胎中6胎染色体正常,5胎21-三体胎儿,二者21-三体胎儿发生率的差异有统计学意义(P=0.002)。结论鼻骨发育异常、且同时合并其他系统异常的胎儿为21-三体的风险较高;而孤立性鼻骨发育异常胎儿染色体异常的风险较小。
[Abstract]:Objective to evaluate the value of solitary nasal bone dysplasia in predicting 21 trisomy fetus. Methods 32 fetuses with abnormal nasal bone were analyzed retrospectively in 1132 weeks gestation. 32 fetuses with abnormal nasal bone were divided into two groups. The incidence of 21 trisomy between the two groups was compared by Fisher exact probability method. Results the incidence of 21 trisomy was compared with that of non solitary nasal bone dysplasia (11 fetuses with other abnormalities at the same time). Results the incidence of 21 trisomy in the two groups was compared by using the exact probability method of Fisher. The chromosome results of 21 embryos in abnormal group were normal. There was significant difference in the incidence of 21 trisomy between 21 trisomy and 5 trisomy 21 in 11 cases of non isolated nasal bone dysplasia. Conclusion the nasal bone development is abnormal, and there is no significant difference in the incidence of 21 trisomy fetus between the two groups. Conclusion there is a significant difference in the incidence of 21 trisomy fetus between the two groups. At the same time, the risk of 21 trisomy was higher in the fetuses with other abnormal systems, while the risk of chromosomal abnormalities in the isolated nasal bone dysplasia fetus was lower.
【作者单位】：广东省人民医院广东省医学科学院超声科;
【基金】：广东省医学科研基金(A2014050)
【分类号】：R714.53;R445.1

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