Numb与P53蛋白在上皮性卵巢癌组织中的表达及临床意义

发布时间：2018-03-05 08:26

本文选题：卵巢癌　切入点：Numb　出处：《四川大学学报(医学版)》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨Numb与P53蛋白在上皮性卵巢癌中的表达、相关性及临床意义。方法采用免疫组化PV二步法联合检测Numb与P53蛋白在20例正常卵巢组织、29例良性卵巢肿瘤组织、35例交界性卵巢肿瘤组织及87例上皮性卵巢癌组织中的表达,分析它们的临床意义。结果 Numb蛋白在正常卵巢组织、良性卵巢肿瘤组织、交界性卵巢肿瘤组织及上皮性卵巢癌组织中的阳性表达率分别为5%、13.8%、51.4%、70.1%,呈逐渐升高的趋势(P0.05);不同卵巢癌分期及有无淋巴结转移的上皮性卵巢癌患者Numb蛋白表达率差异有统计学意义(P0.05),而不同年龄、病理类型、分化程度的患者间差异无统计学意义(P0.05)。P53蛋白在正常卵巢组织、良性卵巢肿瘤组织、交界性卵巢肿瘤组织及上皮性卵巢癌组织中的阳性表达率分别为0%、3.4%、28.6%、63.2%,呈逐渐升高的趋势(P0.05);不同病理类型、分化程度、卵巢癌分期及有无淋巴结转移的上皮性卵巢癌患者P53蛋白表达率差异有统计学意义(P0.05),而不同年龄间表达率差异无统计学意义(P0.05)。Numb与P53蛋白在交界性卵巢肿瘤组织和上皮性卵巢癌组织中的表达均呈正相关(r=0.488,P0.05;r=0.231,P0.05)。结论通过联合检测Numb与P53蛋白可能有助于上皮性卵巢癌的早期诊断及预后判断,两种蛋白可能共同参与上皮性卵巢癌的发生发展过程。
[Abstract]:Objective to investigate the expression of Numb and p53 protein in epithelial ovarian carcinoma. Methods the expression of Numb and p53 protein in 29 cases of benign ovarian neoplasms and 35 cases of borderline ovarian tumors and 87 cases of epithelial ovarian carcinoma were detected by immunohistochemical PV two-step method. Results Numb protein was found in normal ovarian tissues and benign ovarian tumor tissues. The positive expression rates of Numb protein in borderline ovarian tumor and epithelial ovarian carcinoma were 513.8and 51.4 / 70.1, respectively. The expression rate of Numb protein was different in different stages of ovarian cancer and in epithelial ovarian cancer with or without lymph node metastasis. There was statistical significance in P0.05, and in different ages, There was no significant difference in pathological type and differentiation between patients with normal ovarian tissue and benign ovarian tumor tissue. The positive expression rates of borderline ovarian tumor and epithelial ovarian carcinoma were 0.3.4and 28.63.2respectively, showing a tendency of increasing gradually (P0.05), different pathological types and differentiation degree. There was a significant difference in p53 protein expression rate between ovarian cancer stage and epithelial ovarian cancer with or without lymph node metastasis (P 0.05), but there was no significant difference between age and age in the expression of p53 protein and p53 protein in borderline ovarian tumors. There was a positive correlation between the expression of Numb and p53 protein in epithelial ovarian carcinoma. Conclusion the combined detection of Numb and p53 protein may be helpful to the early diagnosis and prognosis of epithelial ovarian cancer. Two proteins may be involved in the development of epithelial ovarian cancer.
【作者单位】：四川大学华西第二医院妇产科;
【分类号】：R737.31

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