四川地区外阴营养不良的流行病学及电生理治疗的临床探索

发布时间：2018-03-06 12:17

本文选题：外阴营养不良　切入点：流行病学　出处：《四川大学学报(医学版)》2017年05期 　论文类型：期刊论文

【摘要】：目的了解四川地区外阴营养不良的基本流行病学数据,同时比较其两种亚型(单纯性苔藓型和硬化性苔藓型)电生理治疗的可行性及效果。方法对2010~2015年在四川大学华西第二医院门诊诊断为外阴营养不良的患者进行横断面调查;同时采用前瞻性队列研究的方法,纳入2015年1~12月在本院经病理活检证实为外阴营养不良的患者26例(单纯性苔藓型18例和硬化性苔藓型8例),采集临床数据,包括瘙痒量表评分和皮肤状态评估,由专人采用统一方法进行电生理治疗,记录治疗前后疾病状态的变化。结果 (1)2010~2015年我院妇科门诊诊断为外阴营养不良的患者为33 859例,患病率为1.38%;(2)成都地区(13 870例,40.96%)及川南地区(6 333例,18.70%)患病人群明显多于其它地区;城镇患者(22 998例,67.92%)明显多于农村患者(10 861例,32.08%);(3)除了40~50岁年龄段,单纯性苔藓及硬化性苔癣患病率在其它不同年龄段间的差异均有统计学意义(P0.05)。两组患者经电生理治疗后随访6~12个月,外阴皮肤颜色改善18例(69.23%),瘙痒评分改善22例(84.62%);其中单纯性苔藓组治疗有效率为88.89%(16例),硬化性苔藓组治疗有效率为50.00%(4例),两组间有效率的差异有统计学意义(P0.01)。结论外阴营养不良在四川地区相对常见,且发病具有一定的区域差异;单纯性苔藓型患者更为年轻,且电生理治疗效果更好。
[Abstract]:Objective to understand the basic epidemiological data of vulvar malnutrition in Sichuan Province. At the same time, the feasibility and effect of electrophysiological therapy of two subtypes (simple mossy and sclerosing lichen) were compared. Methods A cross-sectional survey was carried out on the patients diagnosed as vulvar dystrophy in the outpatient clinic of West China Hospital of Sichuan University from 2010 to 2015. At the same time, a prospective cohort study was used to collect clinical data from 26 patients with vulvar dystrophy (18 cases of simple lichen type and 8 cases of sclerosing lichen type) confirmed by pathological biopsy in our hospital from 2015 to December. Including the scale of pruritus and the evaluation of skin condition, the patients were treated by electrophysiologic therapy with unified method. Results from 2010 to 2015, 33,859 patients with vulvar dystrophy were diagnosed as vulvar dystrophy in gynecological outpatient department of our hospital from 2010 to 2015, and the changes of disease state before and after treatment were recorded. The prevalence rate of 13 870 cases (40.96) in Chengdu area and 6 333 cases (18.70%) in Chengdu area was significantly higher than that in other areas, and 22 998 cases (67.92%) in urban areas were significantly more than 10 861 cases (32.08%) in rural areas) except for the 4050 age group. The prevalence of lichen simplex and lichen sclerosus were significantly different among other age groups (P 0.05). The patients in the two groups were followed up for 6 ~ 12 months after electrophysiological therapy. The color of vulvar skin was improved in 18 cases, the pruritus score was improved in 22 cases (84.62%), the effective rate of bryophyte group was 88.89 cases and that of sclerosing lichen moss group was 50.004 cases, the difference between the two groups was statistically significant (P 0.01). Vulvar malnutrition is relatively common in Sichuan, The patients with simple mosses were younger and had better effect of electrophysiologic therapy.
【作者单位】：四川大学华西第二医院妇产科;出生缺陷与相关妇儿疾病教育部重点实验室(四川大学);
【基金】：四川省学术带头人培养基金(No.2012DTPY0028,No.2013RST004) 四川省卫计委基金(No.130113) 四川省科技厅科技支撑计划项目(No.2014KJT057-2014SZ0001)资助
【分类号】：R711.72

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