外泌体在卵巢癌中的研究进展
发布时间:2018-03-07 04:12
本文选题:外泌体 切入点:卵巢癌 出处:《东南大学学报(医学版)》2017年02期 论文类型:期刊论文
【摘要】:卵巢癌是死亡率居首位的女性生殖系统恶性肿瘤。外泌体是由细胞内多囊泡与细胞膜融后释放到细胞外环境中的一种直径在30~100 nm的小囊泡。越来越多的研究发现外泌体是细胞间通讯的关键因子,在肿瘤细胞及肿瘤微环境的物质和信号交流中发挥重要作用。外泌体在卵巢癌的发生发展中亦有重要的调控作用,可能成为卵巢癌诊断和治疗的新靶点。
[Abstract]:Ovarian cancer is the highest mortality malignant tumor of female reproductive system. Exocrine body is a small vesicle which is released into the extracellular environment by the fusion of cell multiple vesicles and cell membrane. More and more studies have found that ovarian cancer is about 30 ~ 100 nm in diameter. Exocrine body is a key factor in intercellular communication. It plays an important role in the communication of substances and signals in tumor cells and tumor microenvironment. Exocrine may also play an important role in the development of ovarian cancer and may become a new target for the diagnosis and treatment of ovarian cancer.
【作者单位】: 南京医科大学附属南京医院妇科;南京医科大学附属南京医院中心实验室;
【基金】:国家自然科学基金资助项目(81572557) 南京市医学科技发展专项资金资助项目(ZKX15029)
【分类号】:R737.31
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本文编号:1577874
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