精子DNA完整性与辅助生殖结局关系的Meta分析

发布时间：2018-03-07 05:13

本文选题：DNA碎片裂　切入点：受精　出处：《中华疾病控制杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的综合分析精子DNA碎片化程度对体外受精(in vitro fertilization,IVF)、卵胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)治疗结果的影响,为提高辅助生殖的临床成功率提供参考依据。方法检索Pub Med、CNKI等相关中英文数据库,筛选纳入精子DNA碎片指数(DNA fragmentation index,DFI)对IVF、ICSI临床结局影响的文献,采用Stata 12.0软件对提取的数据进行分析,报告危险因素的合并相对危险系数RR(95%CI)值。结果本研究最终纳入15篇有效文献,合并RR(95%CI)值分别为:ICSI临床妊娠率0.84(0.63~1.13)在高DFI组与低DFI组之间的差异均无统计学意义(均有P0.05),IVF临床妊娠率0.79(0.67~0.94)、IVF流产率1.69(1.03~2.78)、ICSI流产率2.07(1.22~3.50),除ICSI临床妊娠率以外,各指标差异均有统计学意义(均有P0.05)。结论精子DNA的完整性影响IVF、ICSI治疗结果。
[Abstract]:Objective to analyze the effect of sperm DNA fragmentation on the results of in vitro fertilization vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), or intracytoplasmic sperm injection (ICSI). Methods in order to improve the clinical success rate of assisted reproduction, we searched the Chinese and English databases related to Pub Medi, and screened the literature about the influence of sperm DNA fragment index (fragmentation) on the clinical outcome of IVF. Stata 12.0 software was used to analyze the extracted data, and the combined relative risk coefficient (RRN 95) of risk factors was reported. Results 15 effective literatures were included in this study. There was no significant difference in clinical pregnancy rate between high DFI group and low DFI group (P 0.05%, 0.67 0. 94%). The abortion rate of ICSI was 1.697.32.78. The abortion rate of ICSI was 2.07 ~ 1.22 / 3.50, with the exception of clinical pregnancy rate of ICSI, there was no significant difference between the two groups (P < 0.05), and the clinical pregnancy rate was 0.79 ~ 0.670.64% (P < 0.05), and the clinical pregnancy rate was 1.22 卤3.50% (P < 0.05), and there was no significant difference in the clinical pregnancy rate between the two groups (P < 0.01), and there was no significant difference between the two groups (P < 0.05). Conclusion the integrity of sperm DNA affects the outcome of ICSI treatment.
【作者单位】：安徽医科大学生物化学与分子生物学教研室;安徽安科生物工程(集团)股份有限公司;
【分类号】：R714.8

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