米非司酮预防功能失调性子宫出血宫腔镜术后复发的临床观察

发布时间：2018-03-07 09:48

本文选题：米非司酮　切入点：宫腔镜　出处：《生殖与避孕》2015年10期 　论文类型：期刊论文

【摘要】：目的:探讨米非司酮预防功能失调性子宫出血(dysfunctional uterine bleeding,DUB)宫腔镜子宫内膜电切术(transcervical resection of endometrium,TCRE)后复发的临床疗效。方法:选择诊断为DUB、具有宫腔镜手术指征的患者60例。所有患者术前3个月内行诊断性刮宫术,并经子宫内膜病理检查排除恶性病变。将研究对象随机分为研究组和对照组,各30例,给予TCRE治疗。研究组在术后第1日起,口服米非司酮,剂量为12.5 mg/d,持续3个月,对照组不给予药物处理。于术后1个月、3个月、6个月观察患者的月经情况、血红蛋白(Hb)、子宫内膜厚度及手术疗效。结果:研究组患者术后3个月内均闭经,停药后3例患者出现月经复潮,经量较术前明显减少;对照组术后22例闭经,8例月经复潮,其中3例月经量与术前相当;研究组和对照组术后的平均Hb量均较术前上升,组间相比差异无统计学意义(P0.05);研究组术后子宫内膜平均厚度低于术前和对照组,差异有统计学意义(P0.05)。结论:DUB患者TCRE后辅助口服米非司酮可减少患者月经量,甚至导致闭经,预防DUB复发,提高宫腔镜手术治疗的效果。
[Abstract]:Objective: to investigate the clinical efficacy of mifepristone in preventing the recurrence of dysfunctional uterine bleedingus (DUB) after transcervical resection of endometrium (TCR). All patients underwent diagnostic curettage within 3 months before operation. The subjects were randomly divided into study group and control group, 30 cases in each group were treated with TCRE. The study group was treated with mifepristone at a dose of 12.5 mg / d for 3 months from 1st after operation. In the control group, the menstruation, hemoglobin, endometrial thickness and operative efficacy were observed at 1 month, 3 months and 6 months after operation. Results: the patients in the study group were amenorrhea within 3 months after operation. The menstrual resuscitation occurred in 3 patients after withdrawal, the menstrual volume in 22 patients with amenorrhea was 8 in the control group, and the menstrual volume in 3 patients was similar to that before the operation, and the mean HB level in the study group and the control group was higher than that before the operation. There was no significant difference between the two groups (P 0.05), and the mean thickness of endometrium in the study group was lower than that in the preoperation group and the control group, and the difference was statistically significant (P 0.05). Conclusion Mifepristone supplementation after TCRE in patients with TCRE can reduce the menstrual volume of the patients, and even cause amenorrhea. To prevent the recurrence of DUB and improve the effect of hysteroscopic surgery.
【作者单位】：上海市浦东新区浦南医院妇产科;
【分类号】：R711.52

【参考文献】