CD34及CD44v6在子宫腺肌病中的表达及意义

发布时间：2018-03-07 11:49

本文选题：CD34　切入点：CD44v6　出处：《延边大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：观察CD34及CD44v6在子宫腺肌病中的表达,探讨其在子宫腺肌病发生和发展中的意义。方法：应用免疫组织化学法检测40例子宫腺肌病的异位内膜、在位内膜和10例正常子宫内膜中CD34(微血管密度,MVD)及CD44v6的表达。结果：1.MVD在腺肌病异位内膜、在位内膜及正常子宫内膜中分别为43.58±9.28%、30.95±6.66%、9.40±3.06%,各组比较均具有显著性差异(P0.05)；在位内膜中分泌期和增生期内膜的MVD分别为32.65±6.41%和28.25±6.63%,差异具有统计学意义(P0.05)；正常内膜中增生期和分泌期内膜的MVD无显著性差异(P0.05)。 2.CD44v6在腺肌病异位内膜、在位内膜及正常子宫内膜中的表达分别为33.73±8.22%、26.65±7.73%、13.10±6.97%,各组比较均具有显著性差异(P0.05)；在位内膜中分泌期和增生期内膜的CD44v6表达分别为29.45±7.86%、24.85±7.72%,具有显著性差异(P0.05)；正常内膜中增生期和分泌期内膜的CD44v6表达无显著性差异(P0.05)。 3.CD34与CD44v6在腺肌病的异位内膜中的表达呈正相关(r=0.6962,P0.05)。结论：CD34及CD44v6在子宫腺肌病中表达上调,在位内膜分泌期较增生期表达增强,提示异位内膜促进血管生成,利于异位内膜生长,且与内膜的周期性变化有关：CD34及CD44v6在子宫腺肌病的发生发展和生物学行为中发挥协同作用。
[Abstract]:Aim: to investigate the expression of CD34 and CD44v6 in adenomyosis. Methods: immunohistochemical method was used to detect the expression of CD34 (microvessel density) and CD44v6 in 40 cases of ectopic endometrium, 10 cases of eutopic endometrium and 10 cases of normal endometrium. Results 1. MVD was found in ectopic endometrium of adenomyosis. The MVD of eutopic endometrium and normal endometrium were 43.58 卤9.28 卤30.95 卤6.66 and 9.40 卤3.06, respectively, and the MVD of secretory and proliferative endometrium in eutopic endometrium were 32.65 卤6.41% and 28.25 卤6.63, respectively. There was no significant difference in MVD of secretory endometrium (P 0.05). 2.CD44v6 in ectopic endometrium of adenomyosis, The expressions of CD44v6 in eutopic endometrium and normal endometrium were 33.73 卤8.22 and 26.65 卤7.73, respectively. There were significant differences in the expression of CD44v6 between the eutopic endometrium and normal endometrium (P 0.05), and the expression of CD44v6 in secretory and proliferative endometrium of eutopic endometrium was 29.45 卤7.860.85 卤7.72respectively, there was significant difference in normal endometrial hyperplasia stage (P0.05). There was no significant difference in the expression of CD44v6 between the secretory endometrium and the secretory endometrium (P 0.05). 3. The expression of CD34 and CD44v6 in the ectopic endometrium of adenomyosis was positively correlated with the expression of rn 0.6962P 0.05. Conclusion the expression of CD34 and CD44v6 was up-regulated in adenomyosis and increased in eutopic endometrium during secretory phase, suggesting that ectopic endometrium could promote angiogenesis and facilitate the growth of ectopic endometrium. In addition, CD 34 and CD44v6 play a synergistic role in the occurrence and development of adenomyosis and the biological behavior of adenomyosis.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.71

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