卵巢成熟性囊性畸胎瘤癌变临床病理及基因检测分析

发布时间：2018-03-07 19:50

本文选题：卵巢成熟性囊性畸胎瘤　切入点：癌变　出处：《临床和实验医学杂志》2018年04期 　论文类型：期刊论文

【摘要】：目的探讨卵巢成熟型囊性畸胎瘤恶性病变患者的临床病例特征与基因检测结果。方法回顾性选取2014年至2017年收治的8例卵巢成熟型囊性畸胎瘤恶性病变患者,对患者的临床病理检查结果与血清基因检查结果进行分析。结果 8例患者均为单侧卵巢病变,下腹部疼痛的患者为3例。肿瘤最大径在10 cm以上的患者3例。8例患者中鳞癌3例,腺癌5例。鳞癌影像学检查囊壁存在部分厚度增加,腺癌存在附壁乳头组织,免疫组化检查结果中鳞癌P63与CK5/6为阳性,腺癌Villin、CK20、CDX2为阳性。基因检测发现肠状腺癌恶性病变患者存在KRAS基因突变。结论通过临床检查、超声影像学检查以及血清肿瘤标记因子可以诊断部分卵巢成熟型囊性畸胎瘤恶性病变,KRAS基因突变检查可以辅助诊断是否存在恶性肿瘤病变。
[Abstract]:Objective to investigate the clinical features and gene detection results of ovarian mature cystic teratoma malignant lesions. Methods eight patients with ovarian mature cystic teratoma from 2014 to 2017 were retrospectively selected. The results of clinicopathological examination and serum gene examination were analyzed. There were 3 patients with pain in the lower abdomen, 3 patients with squamous cell carcinoma and 5 patients with adenocarcinoma with the largest tumor diameter over 10 cm. The cystic wall of squamous cell carcinoma was partly thickened and the papilla tissue attached to the wall was found in adenocarcinoma. The results of immunohistochemical examination showed that p63 and CK5/6 were positive in squamous cell carcinoma, and Villin CK20 CDX2 was positive in adenocarcinoma. The mutation of KRAS gene was found in malignant lesions of intestinal adenocarcinoma by gene detection. Ultrasound imaging and serum tumor markers can be used to diagnose malignant lesions of ovarian mature cystic teratoma.
【作者单位】：四川省遂宁市中心医院病理科;
【基金】：四川省遂宁市市级科研课题(编号:2015S02) 遂宁市中心医院院级科研课题(编号:2015Y02)
【分类号】：R737.31

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