不同促排卵方法对卵巢储备功能下降患者的疗效

发布时间：2018-03-08 12:01

本文选题：促排卵　切入点：卵巢储备功能下降　出处：《实用临床医药杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的观察和分析不同促排卵方法对卵巢储备功能下降(DOR)患者的疗效。方法选取120例行体外受精-胚胎移植(IVF-ET)术的DOR患者,分别应用促性腺激素释放激素激动剂(GnRH-a)长方案(A组,39个周期)、GnRH-a短方案(B组,45个周期)及促性腺激素释放激素拮抗剂(GnRH-ant)方案(C组,36个周期)进行促排卵。对3组患者的促性腺激素(Gn)用药量及用药时间,注射人绒毛膜促性腺激素(h CG)日的血清黄体生成素(LH)、雌二醇(E2)水平,子宫内膜厚度及获卵数,受精率、卵裂率、种植率和临床妊娠率进行比较。结果 A组患者的Gn用药时间和用药量均显著多于B组和C组,且C组患者的Gn用药时间显著长于B组(q=2.756~3.936,P0.05),B组患者在注射h CG日的血清E2水平显著高于A组和C组(q=2.638~3.145,P0.05)。3组患者的获卵数、受精数、卵裂数、种植率、临床妊娠率均无显著差异(P0.05)。结论在DOR患者IVF-ET术中应用GnRH-a短方案可减少Gn用量和使用时间,改善患者血清激素水平。
[Abstract]:Objective to observe and analyze the efficacy of different ovulation promotion methods in patients with ovarian reserve dysfunction. Methods 120 DOR patients undergoing IVF-ETS were selected. Ovulation was induced by gonadotropin releasing hormone agonist GnRH-a (GnRH-a) long regimen A, GnRH-a short regimen B (45 cycles) and gonadotropin releasing hormone antagonist (GnRH-antant) group C (36 cycles). The amount of gonadotropin (Gn) used and the duration of the treatment, Serum luteinizing hormone (LHH), estradiol E _ 2 (E _ 2), endometrial thickness and egg count, fertilization rate, cleavage rate, serum luteinizing hormone (LHH) and estradiol E _ 2 (E _ 2) on the day of human chorionic gonadotropin (hCG) injection. Results the duration and dosage of Gn in group A were significantly longer than those in group B and C. The serum E2 level in group C was significantly longer than that in group B (2.756 ~ 3.936 ~ 3.936 ~ 3.936) on the day of hCG injection, which was significantly higher than that in group A and C (2.638 ~ 3.145p _ 0.05C), and the number of oocytes, fertilization, cleavage and implantation rate were significantly higher in group C than in group B, and the serum E _ 2 level in group B was significantly higher than that in group A and C, respectively. There was no significant difference in clinical pregnancy rate (P 0.05). Conclusion the short regimen of GnRH-a during IVF-ET in DOR patients can reduce the dosage and duration of Gn, and improve the serum hormone level in patients with IVF-ET.
【作者单位】：湖北省妇幼保健院;
【分类号】：R714.8

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