上海交通大学医学院附属和平妇幼保健院黄荷凤教授发表女性高雄激素症致子代胚源性疾病研究进展

发布时间：2018-03-08 19:27

本文选题：传代效应　切入点：生殖内分泌疾病　出处：《上海交通大学学报(医学版)》2017年02期 　论文类型：期刊论文

【摘要】：正上海交通大学医学院附属和平妇幼保健院黄荷凤院长领衔的课题组发现,女性妊娠前高雄激素症可能增加子代糖代谢异常的风险,而表观遗传改变的传代效应可能是其分子机制之一。这项研究成果近日在线发表于Cell出版社和The Lancet杂志支持的EBio Medicine杂志。高雄激素症是育龄期妇女常见的生殖内分泌疾病之一,其发生率在不孕人群中高达15%。既往的研究表明,卵泡内过多的雄激素干扰卵子发育潜能,并进一步影响受精和胚胎发育。近年来,通过辅助生殖技术的应用,高雄激素症
[Abstract]:The research group headed by Huang Hefeng, director of Heping Maternal and Child Health Institute, affiliated to the School of Medicine of Shanghai Jiaotong University, found that prepregnancy hyperandrogen may increase the risk of abnormal glucose metabolism in offspring. The epigenetic effect may be one of its molecular mechanisms. The study was published online in the journal EBio Medicine, supported by Cell Press and The Lancet. Hyperandrogenia is one of the most common reproductive endocrine diseases in women of reproductive age. Previous studies have shown that too much androgen in the follicle interferes with egg development potential and further affects fertilization and embryo development. In recent years, the use of assisted reproductive technology has led to hyperandrogenia
【分类号】：R714.2

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