胎儿镜在白化病产前诊断中的临床应用

发布时间：2018-03-09 14:48

本文选题：胎儿镜　切入点：产前诊断　出处：《中国全科医学》2017年06期 　论文类型：期刊论文

【摘要】：背景白化病产前诊断是围生医学的一个难题,胎儿镜是目前临床用于白化病产前诊断的重要方法,但操作较复杂,存在操作失败、误诊等可能。目的探讨胎儿镜在白化病产前诊断中的应用价值、相关临床经验及操作技术。方法选择2009年1月—2015年6月在首都医科大学附属北京妇产医院产科就诊的28例孕有白化病高风险胎儿的孕妇,于孕19~27周,在B超引导下于羊水池最深处应用胎儿镜进入羊膜腔,观察胎儿头发颜色,进行白化病产前诊断。结果 28例孕妇均成功接受胎儿镜检查。胎儿镜操作时间为8~42 min,平均16 min。20例诊断为正常胎儿;8例诊断为白化病胎儿,其流产后病理诊断均明确为白化病胎儿。胎儿镜在白化病产前诊断中的失败率及误诊率均为0。结论胎儿镜用于白化病等遗传性疾病产前诊断,具有快速、准确、安全等特点,对于合并羊水少的孕妇可联合行羊膜腔灌注,缩短胎儿镜操作时间。
[Abstract]:Background Prenatal diagnosis of albinism is a difficult problem in perinatal medicine. Foetus endoscopy is an important method for prenatal diagnosis of albinism. Objective to explore the value of fetal endoscopy in prenatal diagnosis of albinism. Methods 28 pregnant women with high risk of albinism were selected from January 2009 to June 2015 in Beijing Obstetrics and Obstetrics Hospital affiliated to Capital Medical University. Under the guidance of B-mode ultrasound, fetal lens was used to enter the amniotic cavity in the deepest part of the goat pool to observe the color of fetal hair. Results 28 cases of pregnant women were successfully examined with fetal endoscopy. The operating time of fetal endoscopy was 842 mins, and the average of 16 min.20 cases was diagnosed as normal fetus, 8 cases were diagnosed as albino fetus, 8 cases were diagnosed as albino fetus, and 8 cases were diagnosed as normal fetus. The failure rate and misdiagnosis rate of fetal lens in prenatal diagnosis of albinism were both 0.Conclusion Fetal lens is rapid, accurate and safe in prenatal diagnosis of hereditary diseases such as albinism. For pregnant women with oligohydramnios, amniotic cavity perfusion can be combined to shorten the operation time of fetal endoscopy.
【作者单位】：首都医科大学附属北京妇产医院产科;
【分类号】：R714.5

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