D-二聚体联合妊娠相关蛋白A对稽留流产的预测价值

发布时间：2018-03-10 19:13

本文选题：妊娠相关蛋白A　切入点：D-二聚体　出处：《广东医学》2017年S1期 　论文类型：期刊论文

【摘要】：目的探讨妊娠相关蛋白A及D-二聚体在早期妊娠孕妇血清中的浓度变化,研究两者对稽留流产的预测作用。方法应用酶联免疫法检测80例早期妊娠孕妇血清中妊娠相关蛋白A及D-二聚体的浓度变化。结果正常妊娠与先兆流产组之间妊娠相关蛋白A浓度在孕8、10及12周时均无明显差异。稽留流产组妊娠相关蛋白A浓度在孕10、12周时明显低于正常妊娠及先兆流产组,组间差异有统计学意义(P0.05)。稽留流产患者血清D-二聚体明显高于先兆流产及正常妊娠孕妇(P0.05)。妊娠相关蛋白A诊断稽留流产的截断点为14.25 m IU/L。D-二聚体诊断稽留流产的截断点为3.02 mg/L。妊娠相关蛋白A及D-二聚体二者串联时的敏感度为71.3%特异度为93.6%,两者并联时的敏感度为94.5%,特异度为50.1%。结论联合检测患者血清妊娠相关蛋白A及D-二聚体,可提高早期稽留流产的诊断率,减少误诊和漏诊。
[Abstract]:Objective to investigate the changes of serum concentration of pregnancy-associated protein A and D-dimer in early pregnant women. Methods Enzyme-linked immunosorbent assay (Elisa) was used to detect the concentration of pregnancy-associated protein A and D-dimer in the serum of 80 pregnant women with early pregnancy. The concentration of pregnancy-associated protein A in missed abortion group was significantly lower than that in normal pregnancy group and threatened abortion group. The serum D- dimer in patients with missed abortion was significantly higher than that in pregnant women with threatened abortion and normal pregnancy (P 0.05). The cut-off point of pregnancy-associated protein A in the diagnosis of missed abortion was 14.25 m IUL / L.D- dimer for missed abortion. The sensitivity of pregnancy-associated protein A and D-dimer in series was 93.6, the sensitivity of the two in parallel connection was 94.55.The specificity was 50.1Conclusion the serum levels of pregnancy-associated protein A and D-dimer were detected. It can improve the diagnosis rate of early missed abortion and reduce misdiagnosis and missed diagnosis.
【作者单位】：深圳市宝安区人民医院妇科;
【基金】：深圳市宝安区科技计划社会公益项目(编号:2015057)
【分类号】：R714.21

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