三伏贴对妊娠期哮喘慢性持续期患者的治疗效果研究

发布时间：2018-03-11 02:31

本文选题：妊娠并发症　切入点：哮喘　出处：《中国全科医学》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨三伏贴对妊娠期哮喘慢性持续期患者的治疗效果。方法选取2010年1月—2014年1月到华北理工大学附属医院就诊的妊娠期哮喘慢性持续期患者120例。按照随机数字表法,将其分为对照组和试验组各60例。对照组采用布地奈德雾化吸入治疗,试验组在对照组的治疗基础上加用三伏贴治疗。分别于治疗前和试验组末次贴敷结束10 d后,检测两组肺功能、炎性因子及相关因素水平,同时记录两组临床疗效和不良反应发生情况。结果对照组有57例完成了治疗,试验组58例,两组平均年龄、平均病程及疾病程度比较,差异无统计学意义(P0.05)。治疗前两组第1秒用力呼气末容积(FEV1)、呼气峰流量(PEF)、FEV_1与用力肺活量比值(FEV_1/FVC)比较,差异无统计学意义(P0.05);治疗后两组FEV_1、PEF及FEV_1/FVC比较,差异有统计学意义(P0.05);治疗后两组FEV_1、PEF及FEV_1/FVC与治疗前比较,差异均有统计学意义(P0.05)。治疗前两组血清转化生长因子β_1(TGF-β_1)、肿瘤坏死因子α(INF-α)、γ-干扰素(IFN-γ)、辅助性T细胞(Th17)、皮质醇及瘦素水平比较,差异无统计学意义(P0.05)。治疗后两组血清TGF-β_1、INF-α、IFN-γ、Th17、皮质醇及瘦素水平比较,差异有统计学意义(P0.05)。治疗后两组血清TGF-β_1、INF-α、IFN-γ、Th17、皮质醇及瘦素水平与治疗前比较,差异均有统计学意义(P0.05)。两组临床疗效比较,差异有统计学意义(P0.05)。两组不良反应发生率比较,差异无统计学意义(P0.05)。结论三伏贴治疗妊娠期哮喘慢性持续期的临床疗效确切,可以改善患者肺功能、血清炎性因子及相关因素水平,且不良反应较少。
[Abstract]:Objective to investigate the therapeutic effect of Sanfu paste on chronic continuous pregnancy asthma patients. Methods 120 patients with chronic pregnancy asthma were selected from January 2010 to January 2014 in the affiliated Hospital of North China University of Technology. The control group was treated with budesonide atomization inhalation, and the experimental group was treated with three volt patches on the basis of the treatment of the control group, respectively, before the treatment and 10 days after the end of the last application in the test group, the treatment group was treated with budesonide nebulization. Pulmonary function, inflammatory factors and related factors were measured, and clinical efficacy and adverse reactions were recorded in both groups. Results 57 cases in the control group completed the treatment, 58 cases in the experimental group, and the average age of the two groups. There was no significant difference in the mean course of disease and the degree of disease between the two groups before treatment (P 0.05). There was no significant difference in FEV1 / FVC-1 and FEV1 / FVC-1 between the two groups before and after treatment, but there was no significant difference in FEV1 / FVC-1 and FEV_1/FVC between the two groups before and after treatment, and there was no significant difference in FEV1 / FVC-1 and FEV1 / FVC-1 between the two groups before and after treatment, and there was no significant difference in FEV1 / FVC1 between the two groups before treatment. There were significant differences in FEV-1 PEF and FEV_1/FVC between the two groups before and after treatment. The levels of serum TGF- 尾 1, TGF- 尾 1, TNF- 伪, IFN- 纬, Th17P, cortisol and leptin were compared between the two groups before treatment. There was no significant difference in serum TGF- 尾 1INF- 伪 IFN- 纬 Th17, cortisol and leptin levels in the two groups after treatment. After treatment, the serum TGF- 尾 1INF- 伪 -IFN- 纬 Th17, cortisol and leptin levels were compared with those before treatment. There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion the clinical efficacy of Sanfu plaster in the treatment of chronic asthma complicating pregnancy is accurate, and there is no significant difference in the incidence of adverse reactions between the two groups, and there is no significant difference in the incidence of adverse reactions between the two groups. Can improve the pulmonary function, serum inflammatory factors and related factors, and less adverse reactions.
【作者单位】：华北理工大学中医学院;
【基金】：国际科技合作计划项目(2013DFG31080) 国家自然科学基金资助项目(81303046)
【分类号】：R714.253

【相似文献】