卵巢癌组织己糖激酶2、6磷酸果糖激酶1、丙酮酸激酶表达变化及其意义

发布时间：2018-03-11 10:07

本文选题：卵巢癌　切入点：糖酵解　出处：《山东医药》2017年35期 　论文类型：期刊论文

【摘要】：目的观察卵巢癌组织中己糖激酶2(HK-2)、6磷酸果糖激酶1(PFK1)、丙酮酸激酶(PK)表达变化,并探讨其意义。方法采用免疫组化法检测100例卵巢癌患者肿瘤组织(观察组)及癌旁组织(对照组)中的HK-2、PFK1、PK。分析卵巢癌组织中HK-2、PFK1、PK表达与卵巢癌临床病病理参数的关系。结果观察组HK-2表达阳性56例(56%)、PFK1表达阳性62例(62%)、PK表达阳性53例(53%),对照组分别为8例(8%)、11例(11%)、10例(10%)。观察组HK-2、PFK1、PK阳性表达率高于对照组,P均0.05。HK-2、PFK1、PK阳性表达率高于对照组,P0.05。卵巢癌组织中HK-2、PFK1、PK阳性表达与卵巢癌临床分期、淋巴结转移及远处转移有关(P均0.05),与患者年龄、组织学类型、分化程度无关(P均0.05)。HK-2、PFK1、PK表达阳性和HK-2、PFK1、PK表达阴性的卵巢癌患者2年累积复发率相比P均0.05。结论卵巢癌组织HK-2、PFK1、PK表达上调。检测卵巢癌组织HK-2、PFK1、PK有助于判断卵巢癌患者病情。
[Abstract]:Objective to observe the expression of hexokinase 2HK-2O6 phosphofructokinase 1 (PFK1) and pyruvate kinase (PKK) in ovarian carcinoma. Methods Immunohistochemical method was used to detect the expression of HK-2pPFK1PK in tumor tissues of 100 patients with ovarian cancer (observation group) and paracancerous tissues (control group). The expression of HK-2pPFK1 PK and clinicopathological parameters of ovarian cancer were analyzed. Results there were 56 cases of positive expression of HK-2 in observation group and 62 cases of positive expression of PFK1 in 62 cases. There were 53 cases of PK positive in observation group and 11 cases in control group, respectively. The positive rate of PKexpression in observation group was higher than that in control group (P 0.05.HK-2PFK1P). P0.05.The positive expression of HK-2pPFK1 protein and the clinical stage of ovarian cancer were observed. Lymph node metastasis and distant metastasis were associated with P 0.05, and were associated with age and histological type. The 2-year cumulative recurrence rate of ovarian cancer patients with negative expression of HK-2pPFK1pK was higher than that of patients with ovarian cancer (P 0.05). Conclusion the expression of HK-2pPFK1pPK is up-regulated in ovarian cancer tissue, and the detection of HK-2PFK1PK may be helpful in judging the condition of ovarian cancer.
【作者单位】：青海红十字医院;
【分类号】：R737.31

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