热休克因子1（HSF1）表达与宫颈癌临床病理特征及生存的相关性分析

发布时间：2018-03-11 10:45

本文选题：宫颈癌　切入点：热休克因子1　出处：《重庆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:分析宫颈癌组织中热休克因子1(Heat-shock factor 1,HSF1)表达与宫颈癌患者临床病理特征及生存的相关性。方法:收集2009年11月至2013年12月于重庆医科大学附属第一医院妇科直接行手术治疗的FIGO分期为IA~IIA期的宫颈癌病例,检测并分析癌组织中热休克因子HSF1的表达与临床病理特征及无进展生存时间(Progress free suivival,PFS)的相关性。结果:宫颈癌组织中HSF1表达强度与癌细胞肌层浸润深度(P=0.02)呈显著正相关;在高级别病变(P=0.45)、脉管癌栓阳性(P=0.80)及淋巴结阳性(P=0.13)患者组织中HSF1表达高于低级别、无脉管癌栓及淋巴结转移患者,但差异无统计学意义。HSF1表达的高低对这些早期宫颈癌的PFS没有显著影响(P=0.33),但对癌症基因组图谱(The Cancer Genome Atlas,TCGA)中320例宫颈癌患者的基因数据分析显示,HSF1基因表达越强,患者的预后越差(P=0.02)。结论:癌组织中HSF1高强度表达与宫颈癌进展程度直接相关,并可能影响生存。
[Abstract]:Objective: to analyze the relationship between the expression of heat shock factor 1 (1) Heat-shock factor 1 (HSF1) and the clinicopathological features and survival of cervical cancer patients. Methods: from November 2009 to December 2013, we collected from the first affiliated Hospital of Chongqing Medical University, gynecology and gynecology. Cases of cervical cancer with FIGO staging at IA~IIA stage were treated directly by surgery. The relationship between the expression of heat shock factor (HSF1) and the clinicopathological characteristics and the progress free suivivalSs in cervical carcinoma was analyzed. Results: there was a significant positive correlation between the expression of HSF1 and the depth of myometrium invasion (P0. 02) in cervical carcinoma. The expression of HSF1 was higher in the patients with high grade pathological changes than in the patients with lower grade, and no vessel tumor embolus and lymph node metastasis, the expression of HSF1 was higher in the patients with high grade lesions than that in the patients with high grade lesions, positive vascular tumor thrombus or P0. 80) and lymph node positive. However, there was no significant difference in the expression of HSF1. There was no significant effect of HSF1 expression on the PFS of these early cervical carcinomas. However, the analysis of the gene data of 320 patients with cervical cancer in the Cancer Genome TCGA showed that the higher the expression of HSF1 gene was, the stronger the expression of HSF1 gene was. Conclusion: the high expression of HSF1 is directly related to the progression of cervical cancer and may affect the survival of cervical cancer.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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