TCT、HPV、hTERC、C-MYC在新疆维吾尔族宫颈病变筛查中的临床价值

发布时间：2018-03-13 18:14

  本文选题：宫颈癌　切入点：细胞学检查　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨TCT、HPV、端粒酶基因(hTERC)、C-MYC基因在新疆维吾尔族妇女宫颈病变筛查中的临床价值。方法:收集1000例新疆维吾尔族妇女的宫颈脱落细胞行液基细胞学检测(TCT)、高危人乳头瘤病毒检测(HPV)、hTERC、C-MYC基因检测,任一指标阳性,行阴道镜下活检。结果:随着宫颈细胞学及组织学病变程度的增加,HPV、hTERC、C-MYC基因阳性率逐渐增加(P0.05),HPV、hTERC、C-MYC基因扩增在CINⅡ及以上级别病变中的阳性率高于CINⅠ及以下病变(P0.05)。HPV阳性组中hTERC、C-MYC基因的扩增高于HPV阴性组,两组比较差异有统计学意义(P0.05)。在检测宫颈高级别病变(≥CINⅡ),hTERC、C-MYC基因有较高的敏感度、特异度、阴性预测值,TCT、HPV、hTERC、C-MYC基因检测宫颈CINⅡ及以上病变的受试者工作特征曲线(ROC)下面积分别为0.657,0.639,0.879,0.835。结论:1.hTERC及C-MYC基因的扩率随着宫颈病变程度加重而增加,可作为预测宫颈病变进展的重要生物学指标。2.HPV感染与hTERC、C-MYC基因异常扩增之间呈正相关,hTERC、C-MYC基因异常扩增在宫颈癌的发生起着重要作用。3.hTERC、C-MYC基因检测在宫颈CINⅡ及以上高度病变中有较高的筛查价值,对宫颈高度病变的筛查有意义。
[Abstract]:Objective: to investigate the clinical value of TCTH HPVand telomerase gene hTERCU C-MYC gene in screening cervical lesions of Uygur women in Xinjiang. Methods: 1000 cases of Xinjiang Uygur women with cervical exfoliated cells were collected for liquid-based cytological examination. Detection of papillomavirus in HPV-hTERCU C-MYC gene, Either indicator is positive, Results: with the increase of the degree of cervical cytology and histologic lesion, the positive rate of HPV-hTERCnC-MYC gene increased gradually. The positive rate of HPV-hTERCnC-MYC gene amplification in CIN 鈪，

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