高纯度人绝经期促性腺激素在促排卵治疗中的应用研究

发布时间：2018-03-14 07:19

本文选题：高纯度人绝经促性腺激素　切入点：重组FSH　出处：《生殖医学杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨高纯度人绝经期促性腺激素(HP-HMG)在体外受精-胚胎移植(IVF-ET)促排卵治疗中的有效使用方法。方法回顾性分析2013年1月5日至10月30日于中信湘雅生殖与遗传专科医院行IVF-ET助孕的298名患者的临床资料,根据促排卵药物的不同分成2组:单纯使用HP-HMG的138人为第1组,使用重组FSH(rFSH)和HP-HMG的160人为第2组。比较两组患者促排卵过程中卵巢反应、激素水平、用药情况及治疗结局。结果第2组Gn第6天的E2水平[(2 923.06±430.64)pmol/L]显著高于第1组[(2 218.44±1 745.86)pmol/L](P0.05)。第1组HCG日及Gn第6天HCG水平、总Gn用量和Gn天数明显高于第2组[(分别为(1.79±0.78)U/L vs.(0.89±0.59)U/L,(1.38±1.03)U/L vs.(0.48±0.35)U/L,(1 623.02±547.08)U vs.(1 287.53±498.58)U,(9.89±1.57)d vs.(9.35±1.48)d](P0.05)。两组患者的平均获卵数、受精数、优胚数、早期流产率、取消率、中重度卵巢过度刺激综合征(OHSS)发生率、OHSS取消率、宫外孕发生率比较均无显著性差异(P0.05)。第2组患者的妊娠率、着床率和活产率显著高于第1组(分别为81.06%vs.67.29%,62.25%vs.46.60%,74.24%vs.59.81%)(P0.05)。结论在IVF-ET治疗中,使用rFSH和HP-HMG联合促排卵可以获得比单纯应用HP-HMG较高的临床妊娠率。
[Abstract]:Objective to investigate the effective use of high purity human menopausal gonadotropin (HP-HMG) in the treatment of ovulation promotion by IVF-ET.Methods the reproductive and genetic characteristics of Citic Xiangya from January 5th 2013 to October 30th were retrospectively analyzed. The clinical data of 298 patients who received IVF-ET for pregnancy, According to the different ovulation drugs, the patients were divided into two groups: the first group was treated with HP-HMG alone, the second group was treated with recombinant FSHrFSHs and the second group was treated with HP-HMG. The ovarian response and hormone levels during ovulation induction were compared between the two groups. Results the level of E2 on the 6th day of Gn in group 2 was significantly higher than that in group 1 [2218.44 卤1 745.86 pmol / L] on the 6th day of Gn, and the level of HCG in group 1 was significantly higher than that in group 1 on day 6 of HCG and G _ n on day 6, and the level of E _ 2 in group 2 was significantly higher than that in group 1 [2 218.44 卤1 745.86 pmol / L]. The total dosage of Gn and the days of Gn were significantly higher than those of the second group [(1.79 卤0.78 UL vs.(0.89 卤0.59 UL vs.(0.89 卤0.59 U / L, respectively 1.38 卤1.03U / L vs.(0.48 卤0.35U / L 卤0.35U / L) 1.623.02 卤547.08U vs.(1 287.53 卤498.58U9.89 卤1.57U / d vs.(9.35 卤1.48d] P0.05. The average number of eggs, the number of fertilized embryos, the number of excellent embryos, the early abortion rate, the cancellation rate, the rate of cancellations of OHSS were measured. There was no significant difference in the incidence of ectopic pregnancy (P 0.05). The pregnancy rate, implantation rate and live birth rate in group 2 were significantly higher than those in group 1 (81.06vs.67.29vs.46.60g. 74.24vs.59.81P0.050.Conclusion in the treatment of IVF-ET, the pregnancy rate, the implantation rate and the live delivery rate were significantly higher than those in the first group (81.06vs.67.29vs.46.60g / 74.24vs.59.81.Conclusion in the treatment of IVF-ET, The combination of rFSH and HP-HMG can obtain a higher clinical pregnancy rate than that with HP-HMG alone.
【作者单位】：中南大学生殖与干细胞工程研究所;中信湘雅生殖与遗传专科医院;
【分类号】：R714.8

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