图像引导宫颈癌体外自适应放疗的剂量学研究

发布时间：2018-03-14 17:53

本文选题：宫颈肿瘤　切入点：自适应放疗　出处：《安徽医科大学学报》2015年05期 　论文类型：期刊论文

【摘要】：收集6例符合治疗指征的宫颈癌患者,采用西门子的Artiste自适应放疗系统行适形调强放疗,分别于治疗前、8次治疗后、16次治疗后进行图像采集并重新勾画靶区,制定新的计划,分别比较3组计划间靶区与危及器官的剂量学差异与位置变化。结果显示在放疗过程中,治疗靶区体积逐渐缩小,3组计划的靶区剂量差异无统计学意义;膀胱、直肠位置变化较大,其中以头脚方向最为明显;膀胱、直肠的V40、V45、V50在3组计划中依次减少且差异均有统计学意义(P0.05)。结果表明宫颈癌体外离线式自适应放疗可根据图像反馈信息调整计划,对治疗靶区影响较小,但对膀胱、直肠等重要正常器官组织的保护具有积极意义。
[Abstract]:Six patients with cervical cancer who met the treatment criteria were collected and received conformal intensity modulated radiotherapy (IMRT) with Siemens Artiste adaptive radiotherapy system. The images were collected and the target area was redrawn after 8 times of treatment before and after 16 times of treatment, and a new plan was worked out. The dosimetric difference and location of the target area between the three groups were compared. The results showed that there was no significant difference in the dose of target area between the three groups during radiotherapy, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, bladder, The position of rectum changes greatly, especially in the direction of head and foot. The V40 V 45 V 50 of the rectum decreased in turn in the three groups and the difference was statistically significant (P 0.05). The results showed that the external adaptive radiotherapy for cervical cancer could adjust the plan according to the image feedback information, and had little effect on the target area of the treatment, but had a little effect on the bladder. The protection of rectum and other important normal organs is of positive significance.
【作者单位】：安徽医科大学第一附属医院肿瘤放疗科;
【基金】：国家自然科学基金(编号:81201743)
【分类号】：R730.55;R737.33

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